Chin-Ho Chen | Scholars@Duke

Chin-Ho Chen
Professor of Surgery

Current Appointments & Affiliations

Professor of Surgery, Surgery, Surgical Sciences, Surgery 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003

Contact Information

Box 2926 Med Ctr, Durham, NC 27710
Sorf Bldg Room 117, Durham, NC 27710
chinho.chen@duke.edu (919) 684-3819

Background
Education, Training, & Certifications
- Assistant Professor, Microbiology, Meharry Medical College 1998 - 2002
- Assistant Research Professor, Surgery, Duke University 1997 - 1998
- Research Associate, Ctr. For Aids Research, Duke University 1992 - 1997
- Postdoctoral Fellow, Rheumotology, Duke University 1991 - 1992
- Ph.D., University of North Carolina at Chapel Hill 1991
Duke Appointment History
- Associate Professor of Surgery, Surgery, Surgical Sciences, Surgery 2006 - 2012
- Associate Research Professor in Surgery, Surgery, Surgical Sciences, Surgery 2003 - 2006
- Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
- Assistant Research Professor in Surgery, Surgery, Surgical Sciences, Surgery 1997 - 1998
Research
Selected Grants
- Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action awarded by National Institutes of Health 2018 - 2021
- Gnidimacrin and its derivatives against HIV-1 latency awarded by CRDF Global 2018 - 2019
- Plant Anti-HIV Agents awarded by University of North Carolina - Chapel Hill 2009 - 2019
- Quinolizidines as Novel HIV-1 Entry Inhibitors awarded by National Institutes of Health 2016 - 2018
- Intervening with Latent HIV-1 Infection using Gnidimacrin awarded by National Institutes of Health 2014 - 2017
- Regulation of PD-1 as a strategy against chronic HIV-1 infection awarded by National Institutes of Health 2013 - 2016
- Betulinic acid derivatives as anti-HIV agents awarded by National Institutes of Health 2006 - 2016
- Small Molecules that Regulate Proteasome Activity awarded by National Institutes of Health 2009 - 2013
- Identification of anti-HIV agent(s) from Sophora Alkaloids awarded by National Institutes of Health 2008 - 2011
- Dynamic Envelope interactions and HIV-1 Neutralization awarded by National Institutes of Health 2003 - 2008
- TM-SU Interaction in the Native HIV/SIV Env awarded by National Institutes of Health 2001 - 2008
- The Molecular Target of the HIV-1 Entry Inhibitor IC9564 awarded by National Institutes of Health 2003 - 2006
- Mechanisms Of Cd8+ Noncytolytic Inhibition Of Hiv-1 awarded by National Institutes of Health 1996 - 1999
- Neutralization Determinants Of A Primary Hiv-1 Isolate awarded by National Institutes of Health 1997 - 1999
- Peptide Models Of Two Helical Regions In Gp41 Ectodomain awarded by National Institutes of Health 1990 - 1999
- Duke University Center For Aids Research awarded by National Institutes of Health 1993 - 1994
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gao, P, Wang, X, Sun, L, Cheng, X, Poongavanam, V, Kongsted, J, Álvarez, M, Luczkowiak, J, Pannecouque, C, Clercq, ED, Lee, K-H, Chen, C-H, Liu, H, Menéndez-Arias, L, Liu, X, and Zhan, P. "Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors." Chemical Biology & Drug Design (December 17, 2018). Full Text
  - Wu, G, Zalloum, WA, Meuser, ME, Jing, L, Kang, D, Chen, C-H, Tian, Y, Zhang, F, Cocklin, S, Lee, K-H, Liu, X, and Zhan, P. "Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library." European Journal of Medicinal Chemistry 158 (October 2018): 478-492. Full Text
  - Liu, Q, Li, W, Huang, L, Asada, Y, Morris-Natschke, SL, Chen, C-H, Lee, K-H, and Koike, K. "Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui." European Journal of Medicinal Chemistry 156 (August 2018): 618-627. Full Text
  - Rahim, A, Saito, Y, Miyake, K, Goto, M, Chen, C-H, Alam, G, Morris-Natschke, S, Lee, K-H, and Nakagawa-Goto, K. "Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita." Journal of Natural Products 81, no. 7 (July 16, 2018): 1619-1627. Full Text
  - Dong, X-H, Ho, M-H, Liu, B, Hildreth, J, Dash, C, Goodwin, JS, Balasubramaniam, M, Chen, C-H, and Xie, H. "Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV." Scientific Reports 8, no. 1 (June 11, 2018): 8812-null. Full Text
  - Tian, Y, Liu, Z, Liu, J, Huang, B, Kang, D, Zhang, H, De Clercq, E, Daelemans, D, Pannecouque, C, Lee, K-H, Chen, C-H, Zhan, P, and Liu, X. "Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus." European Journal of Medicinal Chemistry 151 (May 2018): 339-350. Full Text
  - Dong, M, Chen, X-Q, Chen, C-H, and Li, R-T. "Terpenes from Euphorbia antiquorum and their anti-HIV activity in vitro." Chemistry & biodiversity (March 22, 2018). Full Text
  - Huang, L, Lai, W-H, Zhu, L, Li, W, Wei, L, Lee, K-H, Xie, L, and Chen, C-H. "Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor." Acs Medicinal Chemistry Letters 9, no. 3 (March 2018): 268-273. Full Text
  - Yan, S-L, Li, Y-H, Chen, X-Q, Liu, D, Chen, C-H, and Li, R-T. "Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity." Phytochemistry 145 (January 2018): 40-47. Full Text
  - Chen, C-H, and Poss, KD. "Regeneration Genetics." Annual Review of Genetics 51 (November 2017): 63-82. (Review) Full Text
  - Dang, Z, Xie, H, Zhu, L, Zhang, Q, Li, Z, Huang, L, and Chen, C-H. "Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors." ACS medicinal chemistry letters 8, no. 11 (November 2017): 1199-1203. Full Text
  - Dong, M, Quan, L-Q, Dai, W-F, Yan, S-L, Chen, C-H, Chen, X-Q, and Li, R-T. "Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata." Planta medica 83, no. 17 (November 2017): 1368-1373. Full Text
  - Wei, L, Wang, H-L, Huang, L, Chen, C-H, Morris-Natschke, SL, Lee, K-H, and Xie, L. "Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus." Bioorganic & medicinal chemistry letters 27, no. 12 (June 2017): 2788-2792. Full Text
  - Wada, S, Tanaka, N, Chen, CH, Morris-Natschke, SL, Lee, KH, and Kashiwada, Y. "Anti-HIV natural products (28): preparation of conjugate for 3-O-acyl betulin derivative and AZT as anti-HIV agents." Planta medica 81, no. S 01 (December 14, 2016): S1-S381.
  - Zhao, Y, Gu, Q, Morris-Natschke, SL, Chen, C-H, and Lee, K-H. "Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1." Journal of Medicinal Chemistry 59, no. 19 (October 2016): 9262-9268. Full Text
  - Zhong, J-D, Zhao, X-W, Chen, X-Q, Li, H-M, Chen, C-H, Xia, X-S, and Li, R-T. "Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri." Archives of pharmacal research 39, no. 6 (June 2016): 771-777. Full Text
  - Liu, N, Wei, L, Huang, L, Yu, F, Zheng, W, Qin, B, Zhu, D-Q, Morris-Natschke, SL, Jiang, S, Chen, C-H, Lee, K-H, and Xie, L. "Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus." Journal of Medicinal Chemistry 59, no. 8 (April 12, 2016): 3689-3704. Full Text
  - Dang, Z, Zhu, L, Lai, W, Bogerd, H, Lee, K-H, Huang, L, and Chen, C-H. "Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors." Acs Medicinal Chemistry Letters 7, no. 3 (March 2016): 240-244. Full Text
  - Jiang, C, Luo, P, Zhao, Y, Hong, J, Morris-Natschke, SL, Xu, J, Chen, C-H, Lee, K-H, and Gu, Q. "Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity." Journal of natural products 79, no. 3 (March 2016): 578-583. Full Text
  - Ho, M-H, Huang, L, Goodwin, JS, Dong, X, Chen, C-H, and Xie, H. "Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis." PloS one 11, no. 2 (January 2016): e0149618-. Full Text
  - Li, J, Goto, M, Yang, X, Morris-Natschke, SL, Huang, L, Chen, C-H, and Lee, K-H. "Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity." Bioorganic & Medicinal Chemistry Letters 26, no. 1 (January 2016): 68-71. Full Text
  - Yan, M, Lu, Y, Chen, C-H, Zhao, Y, Lee, K-H, and Chen, D-F. "Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme." Journal of Natural Products 78, no. 11 (November 12, 2015): 2712-2718. Full Text
  - Lai, W, Huang, L, Zhu, L, Ferrari, G, Chan, C, Li, W, Lee, K-H, and Chen, C-H. "Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β." Journal of Medicinal Chemistry 58, no. 21 (November 3, 2015): 8638-8646. Full Text
  - Li, H-M, Zhou, C, Chen, C-H, Li, R-T, and Lee, K-H. "Flavonoids Isolated from Heat-ProcessedEpimedium koreanumand Their Anti-HIV-1 Activities." Helvetica Chimica Acta 98, no. 8 (August 2015): 1177-1187. Full Text
  - Xu, K, Wang, K, Yang, Y, Yan, D-A, Huang, L, Chen, C-H, and Xiao, Z. "Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome." European journal of medicinal chemistry 98 (June 2015): 61-68. Full Text
  - Dang, Z, Jung, K, Zhu, L, Xie, H, Lee, K-H, Chen, C-H, and Huang, L. "Phenolic diterpenoid derivatives as anti-influenza a virus agents." Acs Medicinal Chemistry Letters 6, no. 3 (March 2015): 355-358. Full Text
  - Gao, J, Fang, C, Xiao, Z, Huang, L, Chen, C-H, Wang, L-T, and Lee, K-H. "Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9." Medchemcomm 6, no. 3 (March 2015): 444-454. Full Text
  - Mantri, CK, Chen, C-H, Dong, X, Goodwin, JS, Pratap, S, Paromov, V, and Xie, H. "Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis." MicrobiologyOpen 4, no. 1 (February 2015): 53-65. Full Text
  - Ho, M-H, Chen, C-H, Goodwin, JS, Wang, B-Y, and Xie, H. "Functional Advantages of Porphyromonas gingivalis Vesicles." Plos One 10, no. 4 (January 2015): e0123448-null. Full Text
  - Dang, Z, Jung, K, Zhu, L, Lai, W, Xie, H, Lee, K-H, Huang, L, and Chen, C-H. "Identification and synthesis of quinolizidines with anti-influenza a virus activity." Acs Medicinal Chemistry Letters 5, no. 8 (August 2014): 942-946. Full Text
  - Mantri, CK, Chen, C, Dong, X, Goodwin, JS, and Xie, H. "Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1." Journal of dental research 93, no. 8 (August 2014): 794-800. Full Text
  - Wu, Z-Y, Liu, N, Qin, B, Huang, L, Yu, F, Qian, K, Morris-Natschke, SL, Jiang, S, Chen, CH, Lee, K-H, and Xie, L. "Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS." ChemMedChem 9, no. 7 (July 2014): 1546-1555. Full Text
  - "Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS." Chemmedchem 9, no. 7 (January 1, 2014): 1546-1555. Full Text
  - Li, R-J, Zhu, R-X, Zhao, Y, Morris-Natschke, SL, Chen, C-H, Wang, S, Zhang, J-Z, Zhou, J-C, Lou, H-X, and Lee, K-H. "Two new cadinane-type sesquiterpenes from the Chinese liverwort Frullania serrata." Natural product research 28, no. 19 (January 2014): 1519-1524. Full Text
  - Asada, Y, Sukemori, A, Watanabe, T, Malla, KJ, Yoshikawa, T, Li, W, Kuang, X, Koike, K, Chen, C-H, Akiyama, T, Qian, K, Nakagawa-Goto, K, Morris-Natschke, SL, Lu, Y, and Lee, K-H. "Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme." Journal of Natural Products 76, no. 5 (May 2013): 852-857. Full Text
  - Whisnant, AW, Bogerd, HP, Flores, O, Ho, P, Powers, JG, Sharova, N, Stevenson, M, Chen, C-H, and Cullen, BR. "In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms." Mbio 4, no. 2 (April 16, 2013): e000193-null. Full Text
  - Dang, Z, Ho, P, Zhu, L, Qian, K, Lee, K-H, Huang, L, and Chen, C-H. "New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1." Journal of Medicinal Chemistry 56, no. 5 (March 2013): 2029-2037. Full Text
  - Qian, K, Bori, ID, Chen, C-H, Huang, L, and Lee, K-H. "Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors." Journal of Medicinal Chemistry 55, no. 18 (September 14, 2012): 8128-8136. Full Text
  - Dang, Z, Qian, K, Ho, P, Zhu, L, Lee, K-H, Huang, L, and Chen, C-H. "Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants." Bioorg Med Chem Lett 22, no. 16 (August 15, 2012): 5190-5194. Full Text Link to Item
  - Sun, L-Q, Zhu, L, Qian, K, Qin, B, Huang, L, Chen, CH, Lee, K-H, and Xie, L. "Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates." Journal of Medicinal Chemistry 55, no. 16 (August 10, 2012): 7219-7229. Full Text
  - Bori, ID, Hung, H-Y, Qian, K, Chen, C-H, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry." Tetrahedron Letters 53, no. 15 (April 2012): 1987-1989. Full Text
  - Dang, Z, Jung, K, Qian, K, Lee, K-H, Huang, L, and Chen, C-H. "Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators." Acs Medicinal Chemistry Letters 3, no. 11 (January 2012): 925-930. Full Text
  - Liu, Y, Qian, K, Wang, C-Y, Chen, C-H, Yang, X, and Lee, K-H. "Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives." Bioorganic and Medicinal Chemistry Letters 22, no. 24 (2012): 7530-7533. Full Text
  - Sun, L-Q, Qin, B, Huang, L, Qian, K, Chen, C-H, Lee, K-H, and Xie, L. "Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors." Bioorganic and Medicinal Chemistry Letters 22, no. 7 (2012): 2376-2379. Full Text
  - Tsou, LK, Chen, C-H, Dutschman, GE, Cheng, Y-C, and Hamilton, AD. "Blocking HIV-1 entry by a gp120 surface binding inhibitor." Bioorganic and Medicinal Chemistry Letters 22, no. 9 (2012): 3358-3361. Full Text
  - Xu, K, Xiao, Z, Tang, YB, Huang, L, Chen, C-H, Ohkoshi, E, and Lee, K-H. "Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors." Bioorganic and Medicinal Chemistry Letters 22, no. 8 (2012): 2772-2774. Full Text
  - Zhou, T, Shi, Q, Chen, C-H, Huang, L, Ho, P, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents." European Journal of Medicinal Chemistry 47, no. 1 (2012): 86-96. Full Text
  - Chen, Y, Cheng, M, Liu, F-Q, Xia, P, Qian, K, Yu, D, Xia, Y, Yang, Z-Y, Chen, C-H, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues." European Journal of Medicinal Chemistry 46, no. 10 (October 2011): 4924-4936. Full Text
  - Qian, K, Kim, S-Y, Hung, H-Y, Huang, L, Chen, C-H, and Lee, K-H. "New betulinic acid derivatives as potent proteasome inhibitors." Bioorganic & Medicinal Chemistry Letters 21, no. 19 (October 2011): 5944-5947. Full Text
  - Lai, W, Huang, L, Ho, P, Montefiori, D, and Chen, C-H. "The role of dynamin in HIV type 1 Env-mediated cell-cell fusion." Aids Research and Human Retroviruses 27, no. 9 (September 2011): 1013-1017. Full Text
  - Wang, Q, Hu, W, Wang, S, Pan, Z, Tao, L, Guo, X, Qian, K, Chen, C-H, Lee, K-H, and Chang, J. "Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents." European Journal of Medicinal Chemistry 46, no. 9 (September 2011): 4178-4183. Full Text
  - Dang, Z, Lin, A, Ho, P, Soroka, D, Lee, K-H, Huang, L, and Chen, C-H. "Synthesis and proteasome inhibition of lithocholic acid derivatives." Bioorg Med Chem Lett 21, no. 7 (April 1, 2011): 1926-1928. Full Text Link to Item
  - Asada, Y, Sukemori, A, Watanabe, T, Malla, KJ, Yoshikawa, T, Li, W, Koike, K, Chen, C-H, Akiyama, T, Qian, K, Nakagawa-Goto, K, Morris-Natschke, SL, and Lee, K-H. "Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from stellera chamaejasm e L." Organic Letters 13, no. 11 (2011): 2904-2907. Full Text
  - Gryder, BE, Guerrant, W, Chen, CH, and Oyelere, AK. "Oxathiazole-2-one derivative of bortezomib: Synthesis, stability and proteasome inhibition activity." Medchemcomm 2, no. 11 (2011): 1083-1083. Full Text
  - Huang, L, Ho, P, Yu, J, Zhu, L, Lee, K-H, and Chen, C-H. "Picomolar dichotomous activity of gnidimacrin against HIV-1." Plos One 6, no. 10 (January 2011): e26677-null. Full Text
  - Liu, H-S, Xu, S-Q, Cheng, M, Chen, Y, Xia, P, Qian, K, Xia, Y, Yang, Z-Y, Chen, C-H, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity." Bioorganic and Medicinal Chemistry Letters 21, no. 19 (2011): 5831-5834. Full Text
  - Tang, Y-B, Zhang, C-M, Fang, C, Hu, C, Huang, L, Chen, C-H, and Xiao, Z-Y. "Design, synthesis and evaluation of novel 2H-1, 4-benzodiazepine-2-ones as inhibitors of HIV-1 transcription." Yaoxue Xuebao 46, no. 6 (2011): 688-694.
  - Tian, X, Qin, B, Wu, Z, Wang, X, Lu, H, Morris-Natschke, SL, Chen, CH, Jiang, S, Lee, K-H, and Xie, L. "Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors." Journal of Medicinal Chemistry 53, no. 23 (December 2010): 8287-8297. Full Text Open Access Copy
  - Xiong, J, Kashiwada, Y, Chen, C-H, Qian, K, Morris-Natschke, SL, Lee, K-H, and Takaishi, Y. "Conjugates of betulin derivatives with AZT as potent anti-HIV agents." Bioorganic & Medicinal Chemistry 18, no. 17 (September 2010): 6451-6469. Full Text
  - Zhou, T, Shi, Q, Chen, C-H, Zhu, H, Huang, L, Ho, P, and Lee, K-H. "Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents." Bioorganic & Medicinal Chemistry 18, no. 18 (September 2010): 6678-6689. Full Text
  - Qin, B, Jiang, X, Lu, H, Tian, X, Barbault, F, Huang, L, Qian, K, Chen, C-H, Huang, R, Jiang, S, Lee, K-H, and Xie, L. "Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors." Journal of Medicinal Chemistry 53, no. 13 (July 2010): 4906-4916. Full Text Open Access Copy
  - Wang, Q, Li, Y, Song, C, Qian, K, Chen, C-H, Lee, K-H, and Chang, J. "Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs." Bioorganic & Medicinal Chemistry Letters 20, no. 14 (July 2010): 4053-4056. Full Text
  - Qian, K, Kuo, R-Y, Chen, C-H, Huang, L, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors." Journal of Medicinal Chemistry 53, no. 8 (April 2010): 3133-3141. Full Text Open Access Copy
  - Lai, W-H, Huang, L, and Chen, C-H. "HIV entry inhibitors: progress in development and application." Yao Xue Xue Bao = Acta Pharmaceutica Sinica 45, no. 2 (February 2010): 131-140. (Review)
  - Tang, J, Qian, K, Zhang, B-N, Chen, Y, Xia, P, Yu, D, Xia, Y, Yang, Z-Y, Chen, C-H, Morris-Natschke, SL, and Lee, K-H. "Anti-AIDS agents 82: Synthesis of seco-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents." Bioorganic and Medicinal Chemistry 18, no. 12 (2010): 4363-4373. Full Text
  - Dang, Z, Lai, W, Qian, K, Ho, P, Lee, K-H, Chen, C-H, and Huang, L. "Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors." J Med Chem 52, no. 23 (December 10, 2009): 7887-7891. Full Text Link to Item
  - Tian, X, Qin, B, Lu, H, Lai, W, Jiang, S, Lee, K-H, Chen, CH, and Xie, L. "Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors." Bioorganic & Medicinal Chemistry Letters 19, no. 18 (September 2009): 5482-5485. Full Text
  - Dang, Z, Huang, L, and Chen, C-H. "HIV-1 maturation inhibitors: An update." Drugs of the Future 34, no. 10 (2009): 797-797. Full Text
  - Dang, Z, Huang, L, and Chen, C-H. "HIV-1 maturation inhibitors: An update." Drugs of the Future 34, no. 10 (2009): 797-802. Full Text
  - Huang, L, and Chen, CH. "Proteasome regulators: activators and inhibitors." Curr Med Chem 16, no. 8 (2009): 931-939. (Review) Link to Item
  - Qian, K, Yu, D, Chen, C-H, Huang, L, Morris-Natschke, SL, Nitz, TJ, Salzwedel, K, Reddick, M, Allaway, GP, and Lee, K-H. "Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents." Journal of Medicinal Chemistry 52, no. 10 (2009): 3248-3258. Full Text
  - Huang, L, Yu, D, Ho, P, Qian, K, Lee, K-H, and Chen, C-H. "Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives." Bioorganic & Medicinal Chemistry 16, no. 14 (July 2008): 6696-6701. Full Text
  - Lai, W, Huang, L, Ho, P, Li, Z, Montefiori, D, and Chen, C-H. "Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1." Antimicrobial Agents and Chemotherapy 52, no. 1 (January 2008): 128-136. Full Text
  - Huang, L, Ho, P, and Chen, C-H. "Activation and inhibition of the proteasome by betulinic acid and its derivatives." FEBS Lett 581, no. 25 (October 16, 2007): 4955-4959. Full Text Link to Item
  - Huang, L, Yu, D, Ho, P, Lee, K-H, and Chen, C-H. "Synthesis and Anti-HIV Activity of Bi-Functional Triterpene Derivatives." Letters in Drug Design & Discovery 4, no. 7 (October 1, 2007): 471-478. Full Text
  - Huang, L, Lai, W, Ho, P, and Chen, CH. "Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor." Aids Research and Human Retroviruses 23, no. 1 (January 2007): 28-32. Full Text
  - Zhou, J, Chen, CH, and Aiken, C. "Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag." Journal of Virology 80, no. 24 (December 2006): 12095-12101. Full Text
  - Xie, H, Belogortseva, NI, Wu, J, Lai, W-H, and Chen, C-H. "Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain." Antimicrobial Agents and Chemotherapy 50, no. 9 (September 2006): 3070-3074. Full Text
  - Yu, D, Sakurai, Y, Chen, C-H, Chang, F-R, Huang, L, Kashiwada, Y, and Lee, K-H. "Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents." Journal of Medicinal Chemistry 49, no. 18 (September 2006): 5462-5469. Full Text
  - Huang, L, Ho, P, Lee, K-H, and Chen, C-H. "Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives." Bioorg Med Chem 14, no. 7 (April 1, 2006): 2279-2289. Full Text Link to Item
  - "The molecular targets of anti-HIV-1 triterpenes, an update." Medicinal Chemistry Reviews Online 2, no. 5 (October 1, 2005): 423-427. (Review)
  - Huang, L, Yuan, X, Yu, D, Lee, KH, and Chen, CH. "Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives." Virology 332, no. 2 (February 2005): 623-628. Full Text
  - Aiken, C, and Chen, CH. "Betulinic acid derivatives as HIV-1 antivirals." Trends in Molecular Medicine 11, no. 1 (January 2005): 31-36. (Review) Full Text
  - Yu, D, Wild, CT, Martin, DE, Morris-Natschke, SL, Chen, C-H, Allaway, GP, and Lee, K-H. "The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV." Expert Opinion on Investigational Drugs 14, no. 6 (2005): 681-693. Full Text
  - Zhou, J, Huang, L, Hachey, DL, Chen, CH, and Aiken, C. "Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles." Journal of Biological Chemistry 280, no. 51 (2005): 42149-42155. Full Text
  - Yuan, X, Huang, L, Ho, P, Labranche, C, and Chen, CH. "Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564." Virology 324, no. 2 (July 2004): 525-530. Full Text
  - Huang, L, Yuan, X, Aiken, C, and Chen, CH. "Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action." Antimicrobial Agents and Chemotherapy 48, no. 2 (February 2004): 663-665. Full Text
  - Yu, D, Chen, C-H, Brossi, A, and Lee, K-H. "Anti-AIDS agents. 60. Substituted 3′R,4′R-di-O-(-)-camphanoyl- 2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents." Journal of Medicinal Chemistry 47, no. 16 (2004): 4072-4082. Full Text
  - Zhou, J, Chen, CH, and Aiken, C. "The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3′, 3′-dimethylsuccinyl}-betulinic acid." Retrovirology 1 (2004). Full Text
  - Zhou, J, Yuan, X, Dismuke, D, Forshey, BM, Lundquist, C, Lee, K-H, Aiken, C, and Chen, CH. "Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation." Journal of Virology 78, no. 2 (January 2004): 922-929. Full Text
  - Huang, L, Zhang, L, and Chen, CH. "Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41." Current Pharmaceutical Design 9, no. 18 (2003): 1453-1462. Full Text
  - Zhu, C, Matthews, TJ, and Chen, C-H. "Neutralization epitopes of the HIV-1 primary isolate DH012." Vaccine 21, no. 23 (2003): 3301-3306. Full Text
  - Huang, L, and Chen, CH. "Molecular targets of anti-HIV-1 triterpenes." Current Drug Targets - Infectious Disorders 2, no. 1 (2002): 33-36.
  - Sun, I-C, Chen, C-H, Kashiwada, Y, Wu, J-H, Wang, H-K, and Lee, K-H. "Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid." Journal of Medicinal Chemistry 45, no. 19 (2002): 4271-4275. Full Text
  - Chen, CH, Jin, L, Zhu, C, Holz-Smith, S, and Matthews, TJ. "Induction and characterization of neutralizing antibodies against a human immunodeficiency virus type 1 primary isolate." Journal of Virology 75, no. 14 (July 2001): 6700-6704. Full Text
  - Holz-Smith, SL, Sun, IC, Jin, L, Matthews, TJ, Lee, KH, and Chen, CH. "Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564." Antimicrobial Agents and Chemotherapy 45, no. 1 (January 2001): 60-66. Full Text
  - Zhu, C-B, Zhu, L, Holz-Smith, S, Matthews, TJ, and Chen, CH. "The role of the third β strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012." Proceedings of the National Academy of Sciences of the United States of America 98, no. 26 (2001): 15227-15232. Full Text
  - Chen, CH, Greenberg, ML, Bolognesi, DP, and Matthews, TJ. "Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41." Aids Research and Human Retroviruses 16, no. 18 (December 2000): 2037-2041. Full Text
  - Cho, MW, Lee, MK, Chen, CH, Matthews, T, and Martin, MA. "Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate." JOURNAL OF VIROLOGY 74, no. 20 (October 2000): 9749-9754. Full Text Link to Item
  - Lacey, SF, Weinhold, KJ, Chen, CH, McDanal, C, Oei, C, and Greenberg, ML. "Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual." Aids Research and Human Retroviruses 14, no. 6 (April 1998): 521-531. Full Text
  - Sun, I-C, Wang, H-K, Kashiwada, Y, Shen, J-K, Cosentino, LM, Chen, C-H, Yang, L-M, and Lee, K-H. "Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents." Journal of Medicinal Chemistry 41, no. 23 (1998): 4648-4657. Full Text
  - Greenberg, ML, Lacey, SF, Chen, CH, Bolognesi, DP, and Weinhold, KJ. "Noncytolytic CD8 T cell-mediated suppression of HIV replication." Springer Seminars in Immunopathology 18, no. 3 (January 1997): 355-369. (Review) Full Text
  - Hashimoto, F, Kashiwada, Y, Cosentino, LM, Chen, C-H, Garrett, PE, and Lee, K-H. "Anti-AIDS agents - XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives." Bioorganic and Medicinal Chemistry 5, no. 12 (1997): 2133-2143. Full Text
  - Kashiwada, Y, Hashimoto, F, Cosentino, LM, Chen, CH, Garrett, PE, and Lee, KH. "Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents." Journal of Medicinal Chemistry 39, no. 5 (March 1996): 1016-1017. Full Text
  - Toso, JF, Chen, CH, Mohr, JR, Piglia, L, Oei, C, Ferrari, G, Greenberg, ML, and Weinhold, KJ. "Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication." The Journal of Infectious Diseases 172, no. 4 (October 1995): 964-973. Full Text
  - Chen, CH, Matthews, TJ, McDanal, CB, Bolognesi, DP, and Greenberg, ML. "A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion." Journal of Virology 69, no. 6 (June 1995): 3771-3777.
  - Huang, L, Kashiwada, Y, Cosentino, LM, Fan, S, Chen, CH, McPhail, AT, Fujioka, T, Mihashi, K, and Lee, KH. "Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs." Journal of Medicinal Chemistry 37, no. 23 (November 1994): 3947-3955. Full Text
  - Matthews, TJ, Wild, C, Chen, CH, Bolognesi, DP, and Greenberg, ML. "Structural rearrangements in the transmembrane glycoprotein after receptor binding." Immunological Reviews 140 (August 1994): 93-104. (Review) Full Text
  - Chen, CH, Weinhold, KJ, Bartlett, JA, Bolognesi, DP, and Greenberg, ML. "CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism." Aids Research and Human Retroviruses 9, no. 11 (November 1993): 1079-1086. Full Text
  - Chen, C-H, and Cheng, Y-C. "The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine." Journal of Biological Chemistry 267, no. 5 (1992): 2856-2859.
  - Chen, C-H, Vazquez-Padua, M, and Cheng, Y-C. "Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity." Molecular Pharmacology 39, no. 5 (1991): 625-628.
  - Cheng, Y-C, Gao, W-Y, Chen, C-H, Vazquez-Padua, M, and Starnes, MC. "DNA polymerases versus HIV reverse transcriptase in AIDS therapy." Annals of the New York Academy of Sciences 616 (1990): 217-223.
  - Chen, C-H, and Cheng, Y-C. "Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine." Journal of Biological Chemistry 264, no. 20 (1989): 11934-11937.
- Conference Papers
  - Huang, L, Lai, W, Zhu, L, and Chen, C-H. "Elimination of HIV-1 latently infected cells by PKC agonist gnidimacrin alone and in combination with a histone deacetylase inhibitor." July 2016. Link to Item
  - Zhou, T, Chen, C-H, Shi, Q, Huang, L, Ho, P, and Lee, K-H. "Design, synthesis and structure-activity relationships of novel dicamphanoyl-2 ',2 '-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents." August 22, 2010. Link to Item
  - Qian, K, Nakagawa-Goto, K, Chen, C-H, Morris-Natschke, S, and Lee, K-H. "Structure-activity relationship study of novel betulinic acid analogs as potent HIV maturation inhibitors." August 16, 2009. Link to Item
  - Sakurai, Y, Yu, D, Chen, C-H, Chang, F-R, and Lee, K-H. "Moronic acid derivatives as novel potent anti-HIV agents." March 26, 2006. Link to Item
  - Lai, W, Huang, L, Ho, P, Yuan, X, and Chen, C-H. "Inhibition of HIV-1 entry by inducing a nonproductive conformational change in gp120." 2005. Full Text Link to Item
  - Yu, DL, Chen, CH, Brossi, A, Kilgore, N, and Lee, KH. "Substituted-3 ' R,4 ' R-dl-(O)-(-)-camphanoyl-2 ',2 '- dimethyldihydropyrano[2,3-F]chromone (DCP) derivatives as potent anti-HIV agents." 227th National Meeting of the American-Chemical Society. Anaheim, CA. March 28, 2004 - April 1, 2004.: AMER CHEMICAL SOC, March 28, 2004. Link to Item
  - LACEY, SF, CHEN, CH, WEINHOLD, RJ, and GREENBERG, ML. "SUPPRESSION OF HIV-1 REPLICATION BY PRIMARY AND TRANSFORMED CD8 CELLS." 1995. Link to Item
  - CHEN, CH, WEINHOLD, KJ, BARTLETT, JA, BOLOGNESI, DP, and GREENBERG, ML. "CD8+T-LYMPHOCYTE-MEDIATED INHIBITION OF HIV-1 LTR TRANSCRIPTION." August 1994. Link to Item
  - CHEN, CH, WEINHOLD, KJ, BARTLETT, JA, MACDOUGALL, MJ, and GREENBERG, ML. "CD8+ T-LYMPHOCYTES FROM ASYMPTOMATIC HIV-1 INFECTED INDIVIDUALS SUPPRESS TAT-MEDIATED HIV-1 LTR TRANSCRIPTION." March 29, 1993. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers