Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Assistant Professor, Microbiology, Meharry Medical College 1998 - 2002
  • Assistant Research Professor, Surgery, Duke University 1997 - 1998
  • Research Associate, Ctr. For Aids Research, Duke University 1992 - 1997
  • Postdoctoral Fellow, Rheumotology, Duke University 1991 - 1992
  • Ph.D., University of North Carolina at Chapel Hill 1991
• 

  Duke Appointment History

  • Associate Professor of Surgery, Surgery, Surgical Sciences, Surgery 2006 - 2012
  • Associate Research Professor in Surgery, Surgery, Surgical Sciences, Surgery 2003 - 2006
  • Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2003
  • Assistant Research Professor in Surgery, Surgery, Surgical Sciences, Surgery 1997 - 1998
• Research
• 

  Selected Grants

  • Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action awarded by National Institutes of Health 2018 - 2021
  • Aloperine derivatives as novel anti-influenza agents awarded by National Institutes of Health 2019 - 2021
  • Plant Anti-HIV Agents awarded by University of North Carolina - Chapel Hill 2009 - 2020
  • Gnidimacrin and its derivatives against HIV-1 latency 2018 - 2019
  • Quinolizidines as Novel HIV-1 Entry Inhibitors awarded by National Institutes of Health 2016 - 2018
  • Intervening with Latent HIV-1 Infection using Gnidimacrin awarded by National Institutes of Health 2014 - 2017
  • Regulation of PD-1 as a strategy against chronic HIV-1 infection awarded by National Institutes of Health 2013 - 2016
  • Betulinic acid derivatives as anti-HIV agents awarded by National Institutes of Health 2006 - 2016
  • Small Molecules that Regulate Proteasome Activity awarded by National Institutes of Health 2009 - 2013
  • Identification of anti-HIV agent(s) from Sophora Alkaloids awarded by National Institutes of Health 2008 - 2011
  • Dynamic Envelope interactions and HIV-1 Neutralization awarded by National Institutes of Health 2003 - 2008
  • TM-SU Interaction in the Native HIV/SIV Env awarded by National Institutes of Health 2001 - 2008
  • The Molecular Target of the HIV-1 Entry Inhibitor IC9564 awarded by National Institutes of Health 2003 - 2006
  • Mechanisms Of Cd8+ Noncytolytic Inhibition Of Hiv-1 awarded by National Institutes of Health 1996 - 1999
  • Neutralization Determinants Of A Primary Hiv-1 Isolate awarded by National Institutes of Health 1997 - 1999
  • Peptide Models Of Two Helical Regions In Gp41 Ectodomain awarded by National Institutes of Health 1990 - 1999
  • Duke University Center For Aids Research awarded by National Institutes of Health 1993 - 1994
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zhao, Hua-Ding, Yan Lu, Min Yan, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Dao-Feng Chen. “Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MS n .” J Nat Prod 83, no. 1 (January 24, 2020): 134–41. https://doi.org/10.1021/acs.jnatprod.9b00993.
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    • Otsuki, Kouharu, Wei Li, Yoshihisa Asada, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora.” Org Lett 22, no. 1 (January 3, 2020): 11–15. https://doi.org/10.1021/acs.orglett.9b03539.
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    • Yang, Jing-Hua, Xin-Yi Wang, Yi-Ping Zhou, Rong Lu, Chin-Ho Chen, Meng-Han Zhang, Yung-Yi Cheng, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Yun-Song Wang. “Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.” Molecules 25, no. 1 (December 26, 2019). https://doi.org/10.3390/molecules25010099.
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    • Jing, Lanlan, Gaochan Wu, Xia Hao, Fisayo A. Olotu, Dongwei Kang, Chin Ho Chen, Kuo-Hsiung Lee, et al. “Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.” Eur J Med Chem 183 (December 1, 2019): 111696. https://doi.org/10.1016/j.ejmech.2019.111696.
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    • Liu, Qingbo, Yung-Yi Cheng, Wei Li, Li Huang, Yoshihisa Asada, Min-Tsang Hsieh, Susan L. Morris-Natschke, Chin-Ho Chen, Kazuo Koike, and Kuo-Hsiung Lee. “Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.” J Med Chem 62, no. 15 (August 8, 2019): 6958–71. https://doi.org/10.1021/acs.jmedchem.9b00339.
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    • Huang, Ya-Si, Yan Lu, Chin-Ho Chen, Kuo-Hsiung Lee, and Dao-Feng Chen. “Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.” J Nat Prod 82, no. 6 (June 28, 2019): 1587–92. https://doi.org/10.1021/acs.jnatprod.9b00088.
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    • Gao, Ping, Xueshun Wang, Lin Sun, Xiqiang Cheng, Vasanthanathan Poongavanam, Jacob Kongsted, Mar Álvarez, et al. “Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors.” Chem Biol Drug Des 93, no. 4 (April 2019): 582–89. https://doi.org/10.1111/cbdd.13455.
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    • Wu, Haifeng, Guoxu Ma, Qinwen Yang, Yindi Zhu, Li Huang, Yu Tian, Xiaoming Yang, et al. “Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.” Eur J Med Chem 166 (March 15, 2019): 159–66. https://doi.org/10.1016/j.ejmech.2019.01.020.
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    • Kang, Dongwei, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, et al. “Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.” J Med Chem 62, no. 3 (February 14, 2019): 1484–1501. https://doi.org/10.1021/acs.jmedchem.8b01656.
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    • Jiang, Xiangyi, Gaochan Wu, Waleed A. Zalloum, Megan E. Meuser, Alexej Dick, Lin Sun, Chin-Ho Chen, et al. “Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.” Rsc Adv 9, no. 50 (2019): 28961–86. https://doi.org/10.1039/c9ra05869a.
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    • Wu, Gaochan, Waleed A. Zalloum, Megan E. Meuser, Lanlan Jing, Dongwei Kang, Chin-Ho Chen, Ye Tian, et al. “Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.” Eur J Med Chem 158 (October 5, 2018): 478–92. https://doi.org/10.1016/j.ejmech.2018.09.029.
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    • Liu, Qingbo, Wei Li, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.” Eur J Med Chem 156 (August 5, 2018): 618–27. https://doi.org/10.1016/j.ejmech.2018.07.020.
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    • Rahim, Abdul, Yohei Saito, Katsunori Miyake, Masuo Goto, Chin-Ho Chen, Gemini Alam, Susan Morris-Natschke, Kuo-Hsiung Lee, and Kyoko Nakagawa-Goto. “Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita.” J Nat Prod 81, no. 7 (July 27, 2018): 1619–27. https://doi.org/10.1021/acs.jnatprod.8b00211.
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    • Dong, Xin-Hong, Meng-Hsuan Ho, Bindong Liu, James Hildreth, Chandravanu Dash, J Shawn Goodwin, Muthukumar Balasubramaniam, Chin-Ho Chen, and Hua Xie. “Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV.” Sci Rep 8, no. 1 (June 11, 2018): 8812. https://doi.org/10.1038/s41598-018-27284-6.
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    • Tian, Ye, Zhaoqiang Liu, Jinghan Liu, Boshi Huang, Dongwei Kang, Heng Zhang, Erik De Clercq, et al. “Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.” Eur J Med Chem 151 (May 10, 2018): 339–50. https://doi.org/10.1016/j.ejmech.2018.03.059.
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    • Dong, Miao, Xuan-Qin Chen, Chin-Ho Chen, and Rong-Tao Li. “Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity.” Chem Biodivers 15, no. 5 (May 2018): e1700560. https://doi.org/10.1002/cbdv.201700560.
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    • Huang, Li, Wei-Hong Lai, Lei Zhu, Wei Li, Lei Wei, Kuo-Hsiung Lee, Lan Xie, and Chin-Ho Chen. “Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.” Acs Med Chem Lett 9, no. 3 (March 8, 2018): 268–73. https://doi.org/10.1021/acsmedchemlett.8b00012.
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    • Yan, Shi-Li, Yan-Hong Li, Xuan-Qin Chen, Dan Liu, Chin-Ho Chen, and Rong-Tao Li. “Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.” Phytochemistry 145 (January 2018): 40–47. https://doi.org/10.1016/j.phytochem.2017.10.006.
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    • Dang, Zhao, Hua Xie, Lei Zhu, Qingye Zhang, Zhijun Li, Li Huang, and Chin-Ho Chen. “Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors.” Acs Medicinal Chemistry Letters 8, no. 11 (November 2017): 1199–1203. https://doi.org/10.1021/acsmedchemlett.7b00376.
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    • Dong, Miao, Li-Qiu Quan, Wei-Feng Dai, Shi-Li Yan, Chin-Ho Chen, Xuan-Qin Chen, and Rong-Tao Li. “Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.” Planta Med 83, no. 17 (November 2017): 1368–73. https://doi.org/10.1055/s-0043-114736.
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    • Wei, Lei, Hui-Ling Wang, Li Huang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Lan Xie. “Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.” Bioorganic & Medicinal Chemistry Letters 27, no. 12 (June 2017): 2788–92. https://doi.org/10.1016/j.bmcl.2017.04.068.
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    • Wada, S., N. Tanaka, C. H. Chen, S. L. Morris-Natschke, K. H. Lee, and Y. Kashiwada. “Anti-HIV natural products (28): preparation of conjugate for 3-O-acyl betulin derivative and AZT as anti-HIV agents.” Planta Medica 81, no. S 01 (December 14, 2016): S1–381.
    • Zhao, Yu, Qiong Gu, Susan L. Morris-Natschke, Chin-Ho Chen, and Kuo-Hsiung Lee. “Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.” J Med Chem 59, no. 19 (October 13, 2016): 9262–68. https://doi.org/10.1021/acs.jmedchem.6b00461.
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    • Zhong, Jin-Dong, Xue-Wei Zhao, Xuan-Qin Chen, Hong-Mei Li, Chin-Ho Chen, Xue-Shan Xia, and Rong-Tao Li. “Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri.” Arch Pharm Res 39, no. 6 (June 2016): 771–77. https://doi.org/10.1007/s12272-016-0750-8.
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    • Liu, Na, Lei Wei, Li Huang, Fei Yu, Weifan Zheng, Bingjie Qin, Dong-Qin Zhu, et al. “Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus.” J Med Chem 59, no. 8 (April 28, 2016): 3689–3704. https://doi.org/10.1021/acs.jmedchem.5b01827.
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    • Jiang, Cheng, Pan Luo, Yu Zhao, Jialing Hong, Susan L. Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee, and Qiong Gu. “Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.” J Nat Prod 79, no. 3 (March 25, 2016): 578–83. https://doi.org/10.1021/acs.jnatprod.5b01012.
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    • Dang, Zhao, Lei Zhu, Weihong Lai, Hal Bogerd, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors.” Acs Med Chem Lett 7, no. 3 (March 10, 2016): 240–44. https://doi.org/10.1021/acsmedchemlett.5b00339.
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    • Ho, Meng-Hsuan, Li Huang, J Shawn Goodwin, Xinhong Dong, Chin-Ho Chen, and Hua Xie. “Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.” Plos One 11, no. 2 (January 2016): e0149618. https://doi.org/10.1371/journal.pone.0149618.
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    • Li, Jizhen, Masuo Goto, Xiaoming Yang, Susan L. Morris-Natschke, Li Huang, Chin-Ho Chen, and Kuo-Hsiung Lee. “Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.” Bioorg Med Chem Lett 26, no. 1 (January 1, 2016): 68–71. https://doi.org/10.1016/j.bmcl.2015.11.029.
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    • Yan, Min, Yan Lu, Chin-Ho Chen, Yu Zhao, Kuo-Hsiung Lee, and Dao-Feng Chen. “Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme.” J Nat Prod 78, no. 11 (November 25, 2015): 2712–18. https://doi.org/10.1021/acs.jnatprod.5b00660.
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    • Lai, Weihong, Li Huang, Lei Zhu, Guido Ferrari, Cliburn Chan, Wei Li, Kuo-Hsiung Lee, and Chin-Ho Chen. “Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.” J Med Chem 58, no. 21 (November 12, 2015): 8638–46. https://doi.org/10.1021/acs.jmedchem.5b01233.
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    • Li, H. M., C. Zhou, C. H. Chen, R. T. Li, and K. H. Lee. “Flavonoids isolated from heat-processed Epimedium koreanum and their anti-HIV-1 activities.” Helvetica Chimica Acta 98, no. 8 (August 1, 2015): 1177–87. https://doi.org/10.1002/hlca.201500123.
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    • Xu, Kai, Ke Wang, Ying Yang, Ding-An Yan, Li Huang, Chin-Ho Chen, and Zhiyan Xiao. “Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome.” Eur J Med Chem 98 (June 15, 2015): 61–68. https://doi.org/10.1016/j.ejmech.2015.05.023.
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    • Dang, Zhao, Katherine Jung, Lei Zhu, Hua Xie, Kuo-Hsiung Lee, Chin-Ho Chen, and Li Huang. “Phenolic diterpenoid derivatives as anti-influenza a virus agents.” Acs Medicinal Chemistry Letters 6, no. 3 (March 2015): 355–58. https://doi.org/10.1021/ml500533x.
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    • Gao, Jiadi, Cheng Fang, Zhiyan Xiao, Li Huang, Chin-Ho Chen, Li-Ting Wang, and Kuo-Hsiung Lee. “Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.” Medchemcomm 6, no. 3 (March 1, 2015): 444–54. https://doi.org/10.1039/C4MD00412D.
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    • Mantri, Chinmay K., Chin-Ho Chen, Xinhong Dong, Jeffery Shawn Goodwin, Siddharth Pratap, Victor Paromov, and Hua Xie. “Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis.” Microbiologyopen 4, no. 1 (February 2015): 53–65. https://doi.org/10.1002/mbo3.221.
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    • Ho, Meng-Hsuan, Chin-Ho Chen, J Shawn Goodwin, Bing-Yan Wang, and Hua Xie. “Functional Advantages of Porphyromonas gingivalis Vesicles.” Plos One 10, no. 4 (2015): e0123448. https://doi.org/10.1371/journal.pone.0123448.
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    • Huang, Li, Katherine Jung, and Chin Ho Chen. “Inhibitory effect of b-AP15 on the 20S proteasome.” Biomolecules 4, no. 4 (October 14, 2014): 931–39. https://doi.org/10.3390/biom4040931.
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    • Dang, Zhao, Katherine Jung, Lei Zhu, Weihong Lai, Hua Xie, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Identification and synthesis of quinolizidines with anti-influenza a virus activity.” Acs Medicinal Chemistry Letters 5, no. 8 (August 2014): 942–46. https://doi.org/10.1021/ml500236n.
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    • Mantri, C. K., C. Chen, X. Dong, J. S. Goodwin, and H. Xie. “Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1.” J Dent Res 93, no. 8 (August 2014): 794–800. https://doi.org/10.1177/0022034514537647.
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    • Wu, Zhi-Yuan, Na Liu, Bingjie Qin, Li Huang, Fei Yu, Keduo Qian, Susan L. Morris-Natschke, et al. “Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS.” Chemmedchem 9, no. 7 (July 2014): 1546–55. https://doi.org/10.1002/cmdc.201400075.
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    • Asada, Yoshihisa, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li, Xinzhu Kuang, et al. “Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.” Journal of Natural Products 76, no. 5 (May 2013): 852–57. https://doi.org/10.1021/np300815t.
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    • Whisnant, Adam W., Hal P. Bogerd, Omar Flores, Phong Ho, Jason G. Powers, Natalia Sharova, Mario Stevenson, Chin-Ho Chen, and Bryan R. Cullen. “In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.” Mbio 4, no. 2 (April 16, 2013): e000193. https://doi.org/10.1128/mBio.00193-13.
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    • Dang, Zhao, Phong Ho, Lei Zhu, Keduo Qian, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.” J Med Chem 56, no. 5 (March 14, 2013): 2029–37. https://doi.org/10.1021/jm3016969.
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    • Liu, Yingqian, Keduo Qian, Chih-Ya Wang, Chin-Ho Chen, Xiaoming Yang, and Kuo-Hsiung Lee. “Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.” Bioorg Med Chem Lett 22, no. 24 (December 15, 2012): 7530–33. https://doi.org/10.1016/j.bmcl.2012.10.041.
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    • Qian, Keduo, Ibrahim D. Bori, Chin-Ho Chen, Li Huang, and Kuo-Hsiung Lee. “Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.” J Med Chem 55, no. 18 (September 27, 2012): 8128–36. https://doi.org/10.1021/jm301040s.
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    • Sun, Lian-Qi, Lei Zhu, Keduo Qian, Bingjie Qin, Li Huang, Chin Ho Chen, Kuo-Hsiung Lee, and Lan Xie. “Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.” J Med Chem 55, no. 16 (August 23, 2012): 7219–29. https://doi.org/10.1021/jm3007678.
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    • Dang, Zhao, Keduo Qian, Phong Ho, Lei Zhu, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.” Bioorg Med Chem Lett 22, no. 16 (August 15, 2012): 5190–94. https://doi.org/10.1016/j.bmcl.2012.06.080.
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    • Tsou, Lun K., Chin-Ho Chen, Ginger E. Dutschman, Yung-Chi Cheng, and Andrew D. Hamilton. “Blocking HIV-1 entry by a gp120 surface binding inhibitor.” Bioorg Med Chem Lett 22, no. 9 (May 1, 2012): 3358–61. https://doi.org/10.1016/j.bmcl.2012.02.079.
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    • Xu, Kai, Zhiyan Xiao, Yan Bo Tang, Li Huang, Chin-Ho Chen, Emika Ohkoshi, and Kuo-Hsiung Lee. “Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.” Bioorg Med Chem Lett 22, no. 8 (April 15, 2012): 2772–74. https://doi.org/10.1016/j.bmcl.2012.02.086.
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    • Bori, Ibrahim D., Hsin-Yi Hung, Keduo Qian, Chin-Ho Chen, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry.” Tetrahedron Letters 53, no. 15 (April 2012): 1987–89. https://doi.org/10.1016/j.tetlet.2012.02.022.
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    • Sun, Lian-Qi, Bingjie Qin, Li Huang, Keduo Qian, Chin-Ho Chen, Kuo-Hsiung Lee, and Lan Xie. “Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.” Bioorg Med Chem Lett 22, no. 7 (April 1, 2012): 2376–79. https://doi.org/10.1016/j.bmcl.2012.02.055.
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    • Dang, Zhao, Kathy Jung, Keduo Qian, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators.” Acs Medicinal Chemistry Letters 3, no. 11 (January 2012): 925–30. https://doi.org/10.1021/ml3001962.
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    • Zhou, Ting, Qian Shi, Chin-Ho Chen, Li Huang, Phong Ho, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.” Eur J Med Chem 47, no. 1 (January 2012): 86–96. https://doi.org/10.1016/j.ejmech.2011.10.025.
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    • Gryder, B. E., W. Guerrant, C. H. Chen, and A. K. Oyelere. “Oxathiazole-2-one derivative of bortezomib: Synthesis, stability and proteasome inhibition activity.” Medchemcomm 2, no. 11 (November 1, 2011): 1083–86. https://doi.org/10.1039/c1md00208b.
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    • Chen, Ying, Ming Cheng, Fa-Qiang Liu, Peng Xia, Keduo Qian, Donglei Yu, Yi Xia, et al. “Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.” Eur J Med Chem 46, no. 10 (October 2011): 4924–36. https://doi.org/10.1016/j.ejmech.2011.07.051.
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    • Liu, Hong-Shan, Shi-Qing Xu, Ming Cheng, Ying Chen, Peng Xia, Keduo Qian, Yi Xia, et al. “Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.” Bioorg Med Chem Lett 21, no. 19 (October 1, 2011): 5831–34. https://doi.org/10.1016/j.bmcl.2011.07.105.
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    • Qian, Keduo, Sang-Yong Kim, Hsin-Yi Hung, Li Huang, Chin-Ho Chen, and Kuo-Hsiung Lee. “New betulinic acid derivatives as potent proteasome inhibitors.” Bioorg Med Chem Lett 21, no. 19 (October 1, 2011): 5944–47. https://doi.org/10.1016/j.bmcl.2011.07.072.
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    • Lai, Weihong, Li Huang, Phong Ho, David Montefiori, and Chin-Ho Chen. “The role of dynamin in HIV type 1 Env-mediated cell-cell fusion.” Aids Res Hum Retroviruses 27, no. 9 (September 2011): 1013–17. https://doi.org/10.1089/AID.2010.0259.
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    • Wang, Qiang, Weidong Hu, Shuyang Wang, Zhenliang Pan, Le Tao, Xiaohe Guo, Keduo Qian, Chin-Ho Chen, Kuo-Hsiung Lee, and Junbiao Chang. “Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.” Eur J Med Chem 46, no. 9 (September 2011): 4178–83. https://doi.org/10.1016/j.ejmech.2011.06.020.
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    • Asada, Yoshihisa, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li, Kazuo Koike, et al. “Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.” Organic Letters 13, no. 11 (June 2011): 2904–7. https://doi.org/10.1021/ol200889s.
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    • Tang, Yan-Boi, Chuan-Ming Zhang, Cheng Fang, Chun Hu, Li Huang, Chin-Ho Chen, and Zhi-Yan Xiao. “[Design, synthesis and evaluation of novel 2H-1, 4-benzodiazepine-2-ones as inhibitors of HIV-1 transcription].” Yao Xue Xue Bao 46, no. 6 (June 2011): 688–94.
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    • Dang, Zhao, Andrew Lin, Phong Ho, Dominique Soroka, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis and proteasome inhibition of lithocholic acid derivatives.” Bioorg Med Chem Lett 21, no. 7 (April 1, 2011): 1926–28. https://doi.org/10.1016/j.bmcl.2011.02.041.
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    • Huang, Li, Phong Ho, Jie Yu, Lei Zhu, Kuo-Hsiung Lee, and Chin-Ho Chen. “Picomolar dichotomous activity of gnidimacrin against HIV-1.” Plos One 6, no. 10 (2011): e26677. https://doi.org/10.1371/journal.pone.0026677.
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    • Tian, Xingtao, Bingjie Qin, Zhiyuan Wu, Xiaofeng Wang, Hong Lu, Susan L. Morris-Natschke, Chin Ho Chen, Shibo Jiang, Kuo-Hsiung Lee, and Lan Xie. “Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.” Journal of Medicinal Chemistry 53, no. 23 (December 2010): 8287–97. https://doi.org/10.1021/jm100738d.
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    • Zhou, Ting, Qian Shi, Chin-Ho Chen, Hao Zhu, Li Huang, Phong Ho, and Kuo-Hsiung Lee. “Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.” Bioorg Med Chem 18, no. 18 (September 15, 2010): 6678–89. https://doi.org/10.1016/j.bmc.2010.07.065.
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    • Xiong, Juan, Yoshiki Kashiwada, Chin-Ho Chen, Keduo Qian, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Yoshihisa Takaishi. “Conjugates of betulin derivatives with AZT as potent anti-HIV agents.” Bioorg Med Chem 18, no. 17 (September 1, 2010): 6451–69. https://doi.org/10.1016/j.bmc.2010.06.092.
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    • Wang, Qiang, Yanfeng Li, Chuanjun Song, Keduo Qian, Chin-Ho Chen, Kuo-Hsiung Lee, and Junbiao Chang. “Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.” Bioorg Med Chem Lett 20, no. 14 (July 15, 2010): 4053–56. https://doi.org/10.1016/j.bmcl.2010.05.090.
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    • Qin, Bingjie, Xingkai Jiang, Hong Lu, Xingtao Tian, Florent Barbault, Li Huang, Keduo Qian, et al. “Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.” J Med Chem 53, no. 13 (July 8, 2010): 4906–16. https://doi.org/10.1021/jm1002952.
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    • Tang, Jian, Keduo Qian, Bei-Na Zhang, Ying Chen, Peng Xia, Donglei Yu, Yi Xia, et al. “Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.” Bioorg Med Chem 18, no. 12 (June 15, 2010): 4363–73. https://doi.org/10.1016/j.bmc.2010.04.089.
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    • Qian, Keduo, Reen-Yun Kuo, Chin-Ho Chen, Li Huang, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.” J Med Chem 53, no. 8 (April 22, 2010): 3133–41. https://doi.org/10.1021/jm901782m.
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    • Lai, Wei-hong, Li Huang, and Chin-ho Chen. “HIV entry inhibitors: progress in development and application.” Yao Xue Xue Bao 45, no. 2 (February 2010): 131–40.
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    • Dang, Zhao, Weihong Lai, Keduo Qian, Phong Ho, Kuo-Hsiung Lee, Chin-Ho Chen, and Li Huang. “Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.” Journal of Medicinal Chemistry 52, no. 23 (December 2009): 7887–91. https://doi.org/10.1021/jm9004253.
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    • Dang, Z., L. Huang, and C. Chen. “HIV-1 maturation inhibitors: An update.” Drugs of the Future 34, no. 10 (October 1, 2009): 797–802. https://doi.org/10.1358/dof.2009.34.10.1428207.
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    • Tian, Xingtao, Bingjie Qin, Hong Lu, Weihong Lai, Shibo Jiang, Kuo-Hsiung Lee, Chin Ho Chen, and Lan Xie. “Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.” Bioorg Med Chem Lett 19, no. 18 (September 15, 2009): 5482–85. https://doi.org/10.1016/j.bmcl.2009.07.080.
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    • Qian, Keduo, Donglei Yu, Chin-Ho Chen, Li Huang, Susan L. Morris-Natschke, Theodore J. Nitz, Karl Salzwedel, Mary Reddick, Graham P. Allaway, and Kuo-Hsiung Lee. “Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.” Journal of Medicinal Chemistry 52, no. 10 (May 2009): 3248–58. https://doi.org/10.1021/jm900136j.
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    • Dang, Z., L. Huang, and C. H. Chen. “HIV-1 maturation inhibitors: An update.” Drugs of the Future 34, no. 10 (January 1, 2009): 797–802. https://doi.org/10.1358/dof.2009.034.10.1428207.
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    • Huang, Li, and Chin Ho Chen. “Proteasome regulators: activators and inhibitors.” Curr Med Chem 16, no. 8 (2009): 931–39. https://doi.org/10.2174/092986709787581860.
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    • Huang, Li, Donglei Yu, Phong Ho, Keduo Qian, Kuo-Hsiung Lee, and Chin-Ho Chen. “Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.” Bioorg Med Chem 16, no. 14 (July 15, 2008): 6696–6701. https://doi.org/10.1016/j.bmc.2008.05.078.
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    • Lai, Weihong, Li Huang, Phong Ho, Zhijun Li, David Montefiori, and Chin-Ho Chen. “Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.” Antimicrob Agents Chemother 52, no. 1 (January 2008): 128–36. https://doi.org/10.1128/AAC.00737-07.
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    • Huang, Li, Phong Ho, and Chin-Ho Chen. “Activation and inhibition of the proteasome by betulinic acid and its derivatives.” Febs Lett 581, no. 25 (October 16, 2007): 4955–59. https://doi.org/10.1016/j.febslet.2007.09.031.
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    • Huang, L., D. Yu, P. Ho, K. H. Lee, and C. H. Chen. “Synthesis and anti-HIV activity of Bif-functional triterpene derivatives.” Letters in Drug Design and Discovery 4, no. 7 (October 1, 2007): 471–78. https://doi.org/10.2174/157018007781788561.
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    • Huang, Li, Weihong Lai, Phong Ho, and Chin Ho Chen. “Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor.” Aids Res Hum Retroviruses 23, no. 1 (January 2007): 28–32. https://doi.org/10.1089/aid.2006.0137.
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    • Zhou, Jing, Chin Ho Chen, and Christopher Aiken. “Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.” J Virol 80, no. 24 (December 2006): 12095–101. https://doi.org/10.1128/JVI.01626-06.
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    • Yu, Donglei, Yojiro Sakurai, Chin-Ho Chen, Fang-Rong Chang, Li Huang, Yoshiki Kashiwada, and Kuo-Hsiung Lee. “Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.” J Med Chem 49, no. 18 (September 7, 2006): 5462–69. https://doi.org/10.1021/jm0601912.
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    • Xie, Hua, Natalya I. Belogortseva, Jie Wu, Wei-Hong Lai, and Chin-ho Chen. “Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.” Antimicrob Agents Chemother 50, no. 9 (September 2006): 3070–74. https://doi.org/10.1128/AAC.01578-05.
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    • Huang, Li, Phong Ho, Kuo-Hsiung Lee, and Chin-Ho Chen. “Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.” Bioorg Med Chem 14, no. 7 (April 1, 2006): 2279–89. https://doi.org/10.1016/j.bmc.2005.11.016.
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    • Zhou, Jing, Li Huang, David L. Hachey, Chin Ho Chen, and Christopher Aiken. “Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.” J Biol Chem 280, no. 51 (December 23, 2005): 42149–55. https://doi.org/10.1074/jbc.M508951200.
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    • Huang, L., and C. H. Chen. “The molecular targets of anti-HIV-1 triterpenes, an update.” Medicinal Chemistry Reviews  Online 2, no. 5 (October 1, 2005): 423–27.
    • Yu, Donglei, Carl T. Wild, David E. Martin, Susan L. Morris-Natschke, Chin-Ho Chen, Graham P. Allaway, and Kuo-Hsiung Lee. “The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.” Expert Opin Investig Drugs 14, no. 6 (June 2005): 681–93. https://doi.org/10.1517/13543784.14.6.681.
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    • Huang, Li, Xiong Yuan, Donglei Yu, K. H. Lee, and Chin Ho Chen. “Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives.” Virology 332, no. 2 (February 2005): 623–28. https://doi.org/10.1016/j.virol.2004.11.033.
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    • Aiken, Christopher, and Chin Ho Chen. “Betulinic acid derivatives as HIV-1 antivirals.” Trends Mol Med 11, no. 1 (January 2005): 31–36. https://doi.org/10.1016/j.molmed.2004.11.001.
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    • Yu, Donglei, Chin-Ho Chen, Arnold Brossi, and Kuo-Hsiung Lee. “Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.” J Med Chem 47, no. 16 (July 29, 2004): 4072–82. https://doi.org/10.1021/jm0400505.
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    • Yuan, Xiong, Li Huang, Phong Ho, Celia Labranche, and Chin Ho Chen. “Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564.” Virology 324, no. 2 (July 2004): 525–30. https://doi.org/10.1016/j.virol.2004.04.009.
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    • Zhou, Jing, Chin Ho Chen, and Christopher Aiken. “The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.” Retrovirology 1 (June 29, 2004): 15. https://doi.org/10.1186/1742-4690-1-15.
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    • Huang, Li, Xiong Yuan, Christopher Aiken, and Chin Ho Chen. “Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.” Antimicrob Agents Chemother 48, no. 2 (February 2004): 663–65. https://doi.org/10.1128/aac.48.2.663-665.2004.
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    • Zhou, Jing, Xiong Yuan, David Dismuke, Brett M. Forshey, Christopher Lundquist, Kuo-Hsiung Lee, Christopher Aiken, and Chin Ho Chen. “Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.” J Virol 78, no. 2 (January 2004): 922–29. https://doi.org/10.1128/jvi.78.2.922-929.2004.
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    • Zhu, Chongbin, Thomas J. Matthews, and Chin Ho Chen. “Neutralization epitopes of the HIV-1 primary isolate DH012.” Vaccine 21, no. 23 (July 2003): 3301–6. https://doi.org/10.1016/s0264-410x(03)00218-4.
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    • Huang, Li, Linda Zhang, and Chin Ho Chen. “Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.” Curr Pharm Des 9, no. 18 (2003): 1453–62. https://doi.org/10.2174/1381612033454720.
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    • Sun, I-Chen, Chin-Ho Chen, Yoshiki Kashiwada, Jiu-Hong Wu, Hui-Kang Wang, and Kuo-Hsiung Lee. “Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.” Journal of Medicinal Chemistry 45, no. 19 (September 2002): 4271–75. https://doi.org/10.1021/jm020069c.
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    • Huang, Li, and Chin Ho Chen. “Molecular targets of anti-HIV-1 triterpenes.” Curr Drug Targets Infect Disord 2, no. 1 (March 2002): 33–36. https://doi.org/10.2174/1568005024605936.
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    • Zhu, C. B., L. Zhu, S. Holz-Smith, T. J. Matthews, and C. H. Chen. “The role of the third beta strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012.” Proc Natl Acad Sci U S A 98, no. 26 (December 18, 2001): 15227–32. https://doi.org/10.1073/pnas.261359098.
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    • Chen, C. H., L. Jin, C. Zhu, S. Holz-Smith, and T. J. Matthews. “Induction and characterization of neutralizing antibodies against a human immunodeficiency virus type 1 primary isolate.” J Virol 75, no. 14 (July 2001): 6700–6704. https://doi.org/10.1128/JVI.75.14.6700-6704.2001.
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    • Holz-Smith, S. L., I. C. Sun, L. Jin, T. J. Matthews, K. H. Lee, and C. H. Chen. “Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.” Antimicrob Agents Chemother 45, no. 1 (January 2001): 60–66. https://doi.org/10.1128/AAC.45.1.60-66.2001.
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    • Chen, C. H., M. L. Greenberg, D. P. Bolognesi, and T. J. Matthews. “Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41.” Aids Res Hum Retroviruses 16, no. 18 (December 10, 2000): 2037–41. https://doi.org/10.1089/088922200750054765.
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    • Cho, M. W., M. K. Lee, C. H. Chen, T. Matthews, and M. A. Martin. “Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate.” J Virol 74, no. 20 (October 2000): 9749–54. https://doi.org/10.1128/jvi.74.20.9749-9754.2000.
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    • Sun, I. C., H. K. Wang, Y. Kashiwada, J. K. Shen, L. M. Cosentino, C. H. Chen, L. M. Yang, and K. H. Lee. “Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.” J Med Chem 41, no. 23 (November 5, 1998): 4648–57. https://doi.org/10.1021/jm980391g.
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    • Lacey, S. F., K. J. Weinhold, C. H. Chen, C. McDanal, C. Oei, and M. L. Greenberg. “Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual.” Aids Res Hum Retroviruses 14, no. 6 (April 10, 1998): 521–31. https://doi.org/10.1089/aid.1998.14.521.
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    • Hashimoto, F., Y. Kashiwada, L. M. Cosentino, C. H. Chen, P. E. Garrett, and K. H. Lee. “Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.” Bioorg Med Chem 5, no. 12 (December 1997): 2133–43. https://doi.org/10.1016/s0968-0896(97)00158-2.
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    • Greenberg, M. L., S. F. Lacey, C. H. Chen, D. P. Bolognesi, and K. J. Weinhold. “Noncytolytic CD8 T cell-mediated suppression of HIV replication.” Springer Semin Immunopathol 18, no. 3 (1997): 355–69. https://doi.org/10.1007/bf00813503.
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    • Kashiwada, Y., F. Hashimoto, L. M. Cosentino, C. H. Chen, P. E. Garrett, and K. H. Lee. “Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.” J Med Chem 39, no. 5 (March 1, 1996): 1016–17. https://doi.org/10.1021/jm950922q.
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    • Toso, J. F., C. H. Chen, J. R. Mohr, L. Piglia, C. Oei, G. Ferrari, M. L. Greenberg, and K. J. Weinhold. “Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication.” J Infect Dis 172, no. 4 (October 1995): 964–73. https://doi.org/10.1093/infdis/172.4.964.
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    • Chen, C. H., T. J. Matthews, C. B. McDanal, D. P. Bolognesi, and M. L. Greenberg. “A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion.” J Virol 69, no. 6 (June 1995): 3771–77.
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    • Huang, L., Y. Kashiwada, L. M. Cosentino, S. Fan, C. H. Chen, A. T. McPhail, T. Fujioka, K. Mihashi, and K. H. Lee. “Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.” Journal of Medicinal Chemistry 37, no. 23 (November 1994): 3947–55. https://doi.org/10.1021/jm00049a014.
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    • Matthews, T. J., C. Wild, C. H. Chen, D. P. Bolognesi, and M. L. Greenberg. “Structural rearrangements in the transmembrane glycoprotein after receptor binding.” Immunol Rev 140 (August 1994): 93–104. https://doi.org/10.1111/j.1600-065x.1994.tb00866.x.
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    • Chen, C. H., K. J. Weinhold, J. A. Bartlett, D. P. Bolognesi, and M. L. Greenberg. “CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism.” Aids Res Hum Retroviruses 9, no. 11 (November 1993): 1079–86. https://doi.org/10.1089/aid.1993.9.1079.
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    • Chen, C. H., and Y. C. Cheng. “The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine.” J Biol Chem 267, no. 5 (February 15, 1992): 2856–59.
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    • Chen, C. H., M. Vazquez-Padua, and Y. C. Cheng. “Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.” Mol Pharmacol 39, no. 5 (May 1991): 625–28.
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    • Cheng, Y. C., W. Y. Gao, C. H. Chen, M. Vazquez-Padua, and M. C. Starnes. “DNA polymerases versus HIV reverse transcriptase in AIDS therapy.” Ann N Y Acad Sci 616 (1990): 217–23. https://doi.org/10.1111/j.1749-6632.1990.tb17842.x.
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    • Chen, C. H., and Y. C. Cheng. “Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.” J Biol Chem 264, no. 20 (July 15, 1989): 11934–37.
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  • Conference Papers

    • Huang, L., W. Lai, L. Zhu, and C. -. H. Chen. “Elimination of HIV-1 latently infected cells by PKC agonist gnidimacrin alone and in combination with a histone deacetylase inhibitor.” In Journal of the International Aids Society, Vol. 19. JOHN WILEY & SONS LTD, 2016.
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    • Zhou, Ting, Chin-Ho Chen, Qian Shi, Li Huang, Phong Ho, and Kuo-Hsiung Lee. “Design, synthesis and structure-activity relationships of novel dicamphanoyl-2 ',2 '-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.” In Abstracts of Papers of the American Chemical Society, Vol. 240. AMER CHEMICAL SOC, 2010.
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    • Qian, Keduo, Kyoko Nakagawa-Goto, Chin-Ho Chen, Susan Morris-Natschke, and Kuo-Hsiung Lee. “Structure-activity relationship study of novel betulinic acid analogs as potent HIV maturation inhibitors.” In Abstracts of Papers of the American Chemical Society, Vol. 238. AMER CHEMICAL SOC, 2009.
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    • Sakurai, Yojiro, Donglei Yu, Chin-Ho Chen, Fang-Rong Chang, and Kuo-Hsiung Lee. “Moronic acid derivatives as novel potent anti-HIV agents.” In Abstracts of Papers of the American Chemical Society, Vol. 231. AMER CHEMICAL SOC, 2006.
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    • Lai, W, Huang, L, Ho, P, Yuan, X, and Chen, C-H. "Inhibition of HIV-1 entry by inducing a nonproductive conformational change in gp120." 2005.  Full Text  Link to Item
    • Yu, D. L., C. H. Chen, A. Brossi, N. Kilgore, and K. H. Lee. “Substituted-3 ' R,4 ' R-dl-(O)-(-)-camphanoyl-2 ',2 '- dimethyldihydropyrano[2,3-F]chromone (DCP) derivatives as potent anti-HIV agents.” In Abstracts of Papers of the American Chemical Society, 227:U8–U8. AMER CHEMICAL SOC, 2004.
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    • LACEY, S. F., C. H. CHEN, R. J. WEINHOLD, and M. L. GREENBERG. “SUPPRESSION OF HIV-1 REPLICATION BY PRIMARY AND TRANSFORMED CD8 CELLS.” In Aids Research and Human Retroviruses, 11:S133–S133. MARY ANN LIEBERT INC PUBL, 1995.
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    • CHEN, C. H., K. J. WEINHOLD, J. A. BARTLETT, D. P. BOLOGNESI, and M. L. GREENBERG. “CD8+T-LYMPHOCYTE-MEDIATED INHIBITION OF HIV-1 LTR TRANSCRIPTION.” In Aids Research and Human Retroviruses, 10:S36–S36. MARY ANN LIEBERT INC PUBL, 1994.
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    • CHEN, C. H., K. J. WEINHOLD, J. A. BARTLETT, M. J. MACDOUGALL, and M. L. GREENBERG. “CD8+ T-LYMPHOCYTES FROM ASYMPTOMATIC HIV-1 INFECTED INDIVIDUALS SUPPRESS TAT-MEDIATED HIV-1 LTR TRANSCRIPTION.” In Journal of Cellular Biochemistry, 75–75. WILEY-LISS, 1993.
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