Samira Musah
Assistant Professor in the Department of Biomedical Engineering
The Musah Lab is interested in understanding how molecular signals and biophysical forces can function either synergistically or independently to guide organ development and physiology, and how these processes can be therapeutically harnessed to treat human disease. Given the escalating medical crisis in nephrology as growing number of patients suffer from kidney disease that can lead to organ failure, the Musah Lab focuses on engineering stem cell fate for applications in human kidney disease, extra-renal complications, and therapeutic development. Dr. Musah’s research interests include stem cell biology and regenerative medicine, molecular and cellular basis of human organ development and disease progression, organ engineering, patient-specific disease models, biomarker identification, therapeutic discovery, tissue and organ transplantation, microphysiological systems including Organ Chips (organs-on-chips) and organoids, matrix biology, mechanotransduction and disease biophysics.
Current Research Interests
Induced pluripotent stem cells (iPS cells), disease mechanisms, regenerative medicine, molecular and cellular basis of human kidney development and disease, organ engineering, patient-specific disease models, biomarkers, therapeutic discovery, tissue and organ transplantation, microphysiological systems including organs-on-chips and organoids, matrix biology, mechanotransduction, mechanobiology, and disease biophysics.
Current Appointments & Affiliations
- Assistant Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2019
- Assistant Professor in Medicine, Medicine, Nephrology, Medicine 2019
- Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- 101 Science Dr., Box 90281, Durham, NC 27708
-
samira.musah@duke.edu
-
Google Scholar
-
Linkedin
-
Musah Lab
- Background
-
Education, Training, & Certifications
- Ph.D., University of Wisconsin - Madison 2013
-
Previous Appointments & Affiliations
- Visiting Assistant Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2018
-
Academic Positions Outside Duke
- Postdoctoral Fellowship, Harvard University. 2013 - 2018
- Recognition
-
In the News
-
MAY 19, 2022 Forbes -
MAY 9, 2022 Forbes -
APR 27, 2022 Pratt School of Engineering -
APR 22, 2022 National Herald -
APR 21, 2022 Duke BME -
JAN 26, 2022 TechWire -
JAN 3, 2022 Duke MEDx -
DEC 6, 2021 Duke MEDx -
MAY 6, 2021 Cell Stem Cell -
APR 29, 2021 Duke Today -
APR 19, 2021 Nature Reviews Molecular Cell Biology -
MAR 30, 2021 Duke University -
OCT 20, 2020 Duke BME Digital Magazine -
AUG 6, 2020 Cell Stem Cell -
MAY 5, 2020 Duke University -
APR 6, 2020 Duke University School of Medicine -
MAR 20, 2020 Duke Today -
FEB 14, 2020 Pratt School of Engineering, Duke University -
FEB 3, 2020 Cell Press -
JAN 9, 2020 LaunchBio -
NOV 25, 2019 Innovation and Entrepreneurship -
NOV 7, 2019 American Society of Nephrology -
NOV 6, 2019 Duke University -
JUL 16, 2019 Clinical Practice Today -
APR 9, 2019 Duke University -
MAR 15, 2019 Duke University -
OCT 21, 2018 Salon -
AUG 13, 2018 Duke University -
JUL 19, 2018 Science & Technology Research News -
JUL 16, 2018 Technology Networks -
JUL 11, 2018 The Bioscientist -
MAY 16, 2018 CPRIT -
OCT 31, 2017 Baxter -
OCT 3, 2017 Physics World -
JUN 14, 2017 NRMN -
MAY 10, 2017 EurekAlert!
-
-
Awards & Honors
- Genentech Research Award. Genentech. June 2021
- Featured, "Women to Watch" series on RegMedNet. RegMedNet. 2021
- George O’Brien Kidney Center Pilot Grant. The George M. O'Brien Kidney Translational Core Center at the University of Michigan (P30 DK081943) . 2021
- 100 inspiring black scientists in America. Cell Press, Cell Mentor. 2020
- Duke Incubation Fund. Duke Innovation and Entrepreneurship Initiative. January 2020
- Functional & Molecular Genomics Core Facility Voucher Program Award. Duke University. January 2020
- MEDx (Medicine & Engineering) Biomechanics of Injury and Injury Repair Grant. Duke MEDx Initiative. 2020
- Whitehead Scholarship in Biomedical Research. Whitehead Foundation. 2020
- Chair's Research Award. Department of Medicine, Duke University. April 2019
- Dr. Samuel M. Nabrit Early Career Scholar. Brown University. 2019
- Early Career Investigator Travel Award. Keystone Symposia. 2019
- CPRIT Scholar. Cancer Prevention & Research Institute of Texas. 2018
- Baxter Young Investigator Award, First-Tier. Baxter International Inc.. 2017
- Fellow. Keystone Symposia Fellowship. 2017
- MIT Rising Stars in Biomedical Engineering and Science. Massachusetts Institute of Technology. 2016
- NIH/NIDDK Nephrology Research Fellowship. NIH-BIDMC . 2016
- Burroughs Wellcome Fund Postdoctoral Enrichment Fellowship. Burroughs Wellcome Fund. 2015
- Dean's Postdoctoral Fellowship. Harvard University. 2014
- First Prize, Novartis Institute for BioMedical Research Postdoctoral Award. Novartis Institute for BioMedical Research. 2014
- UNCF-Merck Postdoctoral Science Research Fellowship. UNCF & Merck Foundation. 2014
- NIH Chemical-Biology Interface Training Grant. NIH. 2011
- National Science Foundation Graduate Research Fellowship. NSF. 2007
- Expertise
-
Subject Headings
- Biomedical materials
- Chronic renal failure
- Developmental Biology
- Developmental biology, pattern formation
- Drug Discovery
- Kidney Diseases
- Mechanotransduction, Cellular
- Muser Mentor
- Nephrotoxicology
- Personalized medicine
- Regeneration (Biology)
- Regenerative Medicine
- Stem Cell Research
- Tissue Engineering
- Research
-
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Inductive repair of human kidney tissues by cell type-specific sensing and reprogramming awarded by University of Michigan 2021 - 2023
- Engineered in vitro model for blood filtration and human kidney disease modeling awarded by International Foundation for Ethical Research 2020 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Tissue-Specific Biomarkers for the Diagnosis of Human Kidney Disease awarded by Regents of the University of Michigan 2021 - 2022
-
External Relationships
- Issued Patent
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Musah, Samira. “Uncovering SARS-CoV-2 kidney tropism.” Nature Reviews. Molecular Cell Biology 22, no. 8 (August 2021): 509. https://doi.org/10.1038/s41580-021-00370-w.Full Text
-
“Introductions to the Community: Early-Career Researchers in the Time of COVID-19.” Cell Stem Cell 27, no. 2 (August 2020): 200–201. https://doi.org/10.1016/j.stem.2020.07.016.Full Text Open Access Copy
-
Burt, Morgan, Rohan Bhattachaya, Arinze E. Okafor, and Samira Musah. “Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions.” Journal of Visualized Experiments : Jove, no. 161 (July 2, 2020). https://doi.org/10.3791/61299.Full Text Open Access Copy
-
Musah, Samira, Nikolaos Dimitrakakis, Diogo M. Camacho, George M. Church, and Donald E. Ingber. “Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.” Nature Protocols 13, no. 7 (July 2018): 1662–85. https://doi.org/10.1038/s41596-018-0007-8.Full Text
-
Musah, Samira, Akiko Mammoto, Thomas C. Ferrante, Sauveur S. F. Jeanty, Mariko Hirano-Kobayashi, Tadanori Mammoto, Kristen Roberts, et al. “Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.” Nature Biomedical Engineering 1 (January 2017): 0069. https://doi.org/10.1038/s41551-017-0069.Full Text
-
Musah, Samira, Paul J. Wrighton, Yefim Zaltsman, Xiaofen Zhong, Stefan Zorn, Matthew B. Parlato, Cheston Hsiao, et al. “Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 38 (September 8, 2014): 13805–10. https://doi.org/10.1073/pnas.1415330111.Full Text
-
Musah, Samira, Stephen A. Morin, Paul J. Wrighton, Daniel B. Zwick, Song Jin, and Laura L. Kiessling. “Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal.” Acs Nano 6, no. 11 (November 2012): 10168–77. https://doi.org/10.1021/nn3039148.Full Text
-
Derda, Ratmir, Samira Musah, Brendan P. Orner, Joseph R. Klim, Lingyin Li, and Laura L. Kiessling. “High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells.” Journal of the American Chemical Society 132, no. 4 (February 2010): 1289–95. https://doi.org/10.1021/ja906089g.Full Text
-
Kikandi, S. N., S. Musah, K. Lee, J. Hassani, S. Rajan, A. Zhou, and O. A. Sadik. “Comparative studies of quercetin interactions with monophosphate nucleotides using UV-Vis spectroscopy and electrochemical techniques.” Electroanalysis 19, no. 19–20 (October 1, 2007): 2131–40. https://doi.org/10.1002/elan.200703954.Full Text
-
Musah, Samira, Rohan Bhattacharya, and Makenzie Bonner. “Harnessing developmental plasticity to pattern kidney organoids,” n.d.Open Access Copy Link to Item
-
Musah, Samira. “Building an artificial kidney from human stem cells,” n.d.Link to Item
-
-
Book Sections
-
Benam, Kambez H., Stephanie Dauth, Bryan Hassell, Anna Herland, Abhishek Jain, Kyung-Jin Jang, Katia Karalis, et al. “Engineered in vitro disease models.,” 10:195–262, 2015. https://doi.org/10.1146/annurev-pathol-012414-040418.Full Text
-
-
Conference Papers
-
Musah, Samira, and Laura L. Kiessling. “Synthetic polymer scaffold supports human embryonic stem cell adhesion and proliferation in defined conditions.” In Abstracts of Papers of the American Chemical Society, Vol. 244. AMER CHEMICAL SOC, 2012.Link to Item
-
-
- Teaching & Mentoring
-
Recent Courses
- BME 494: Projects in Biomedical Engineering (GE) 2022
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering 2022
- BME 791: Graduate Independent Study 2022
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering 2021
- BME 791: Graduate Independent Study 2021
- BME 792: Continuation of Graduate Independent Study 2021
- EGR 393: Research Projects in Engineering 2021
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering 2020
- BME 791: Graduate Independent Study 2020
- EGR 393: Research Projects in Engineering 2020
- Scholarly, Clinical, & Service Activities
-
Service to the Profession
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.