Miles Berger | Scholars@Duke

Miles Berger
Associate Professor of Anesthesiology

My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2020
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2017

Contact Information

201 Trent Drive, 4317 Duke South, Orange Zone, Durham, NC 27710
DUMC Box 3094, Durham, NC 27710
miles.berger@duke.edu (919) 684-8679

Background
Education, Training, & Certifications
- Internship and Residency, Anesthesiology, Duke University School of Medicine 2009 - 2013
- M.D., University of California - San Francisco 2009
- Ph.D., University of California - San Francisco 2007
Duke Appointment History
- Assistant Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2014 - 2020
- Medical Instructor in the Department of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 2013 - 2014
Recognition
In the News
- JUL 12, 2016 Duke Translational Medicine Institute / DukeCTSA
  
  Supplemental Grant Aids Search for Answers to Post-Anesthesia Memory Problems
Expertise
Subject Headings
Research
Selected Grants
- Geroscience signaling metabolites NAD+ and beta-hydroxybutyrate modulating acute neuroinflammation in delirium awarded by Buck Institute for Research on Aging 2020 - 2025
- Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health 2019 - 2024
- Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health 2020 - 2023
- The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care 2016 - 2022
- Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation 2020 - 2022
- Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care 2020 - 2021
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health 2017 - 2021
- A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health 2016 - 2021
- A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation 2018 - 2021
- The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research 2019 - 2021
- 2015 Dennis W. Jahnigen Career Development/GEMSSTAR Program awarded by American Geriatrics Society 2015 - 2020
- The Significance of Perioperative Changes in CSF tau levels in the Elderly awarded by National Institutes of Health 2015 - 2018
- The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society 2014 - 2018
- Educating Anesthesia Residents to Improve Perioperative Care for the Elderly awarded by American Geriatrics Society 2015 - 2017
- Effect of Isoflurane Versus Propofol Anesthesia on Alzheimer's Disease CSF Markers awarded by Minnetronix, Inc 2014 - 2016
External Relationships
- Masimo Inc.- participation in consulting session (with honorarium donated at my request to the Foundation for Anesthesia Education & Research), and material support (EEG monitor loan) for a research study.
- Private consulting income from individual legal cases, one in florida a few years ago, and one current case in Michigan
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Balentine, Courtney J., Jennie Meier, Miles Berger, Joan Reisch, Munro Cullum, Simon C. Lee, Celette Sugg Skinner, and Cynthia J. Brown. “Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients.” J Surg Res 258 (February 2021): 64–72. https://doi.org/10.1016/j.jss.2020.08.054.
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  - Oyeyemi, Deborah M., Mary Cooter, Stacey Chung, Heather E. Whitson, Jeffrey N. Browndyke, Michael J. Devinney, Patrick J. Smith, et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol, December 30, 2020, 891988720978791. https://doi.org/10.1177/0891988720978791.
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  - Berger, Miles, Mary Cooter, Alexander S. Roesler, Stacey Chung, John Park, Jennifer L. Modliszewski, Keith W. VanDusen, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis, December 13, 2020. https://doi.org/10.3233/JAD-200747.
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  - Berger, Miles, and Kamrouz Ghadimi. “Necessary Heroes and Ethos, from Fighting Nazis to COVID-19.” Anesthesiology 133, no. 6 (December 1, 2020): 1307–10. https://doi.org/10.1097/ALN.0000000000003488.
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  - Velkers, Clive, Miles Berger, Sudeep S. Gill, Roderic Eckenhoff, Heather Stuart, Marlo Whitehead, Peter C. Austin, Paula A. Rochon, and Dallas Seitz. “Association Between Exposure to General Versus Regional Anesthesia and Risk of Dementia in Older Adults.” J Am Geriatr Soc, October 6, 2020. https://doi.org/10.1111/jgs.16834.
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  - Balentine, Courtney J., Jennie Meier, Miles Berger, Timothy P. Hogan, Joan Reisch, Munro Cullum, Herbert Zeh, Simon C. Lee, Celette Sugg Skinner, and Cynthia J. Brown. “Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery.” Am J Surg, August 25, 2020. https://doi.org/10.1016/j.amjsurg.2020.08.024.
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  - Vasunilashorn, Sarinnapha M., Michael J. Devinney, Leah Acker, Yoojin Jung, Long Ngo, Mary Cooter, Richard Huang, Edward R. Marcantonio, and Miles Berger. “A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).” J Am Geriatr Soc 68, no. 8 (August 2020): 1874–76. https://doi.org/10.1111/jgs.16538.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - Berger, Miles, Jonathan B. Mark, and Matthias Kreuzer. “Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?” Anesth Analg 130, no. 5 (May 2020): 1274–77. https://doi.org/10.1213/ANE.0000000000004653.
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  - Klinger, Rebecca Y., Brandi Bottiger, and Miles Berger. “A Plague on Both Your Monitors! Are Bispectral Index and Cerebral Oximetry Useful for Reducing Postoperative Cognitive Impairment?” J Cardiothorac Vasc Anesth 34, no. 5 (May 2020): 1182–83. https://doi.org/10.1053/j.jvca.2020.01.001.
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  - Wang, Ping, Ravikanth Velagapudi, Cuicui Kong, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Miles Berger, Harris A. Gelbard, Carol A. Colton, and Niccolò Terrando. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement 16, no. 5 (May 2020): 734–49. https://doi.org/10.1002/alz.12064.
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  - Berger, Miles, Mary Cooter, Katherine Ni, Jake Thomas, Dhanesh K. Gupta, and Miklos D. Kertai. “Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8).” Br J Anaesth 124, no. 3 (March 2020): e38–39. https://doi.org/10.1016/j.bja.2019.12.005.
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  - Cooter, Mary, Katherine Ni, Jake Thomas, Dhanesh K. Gupta, Thomas J. Hopkins, Timothy E. Miller, Michael L. James, Miklos D. Kertai, and Miles Berger. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.” Br J Anaesth 124, no. 1 (January 2020): e4–7. https://doi.org/10.1016/j.bja.2019.09.036.
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  - VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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  - Mahanna-Gabrielli, Elizabeth, Katie J. Schenning, Lars I. Eriksson, Jeffrey N. Browndyke, Clinton B. Wright, Deborah J. Culley, Lis Evered, et al. “Corrigendum to 'State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018' (Br J Anaesth 2019; 123: 464-478).” Br J Anaesth 123, no. 6 (December 2019): 917. https://doi.org/10.1016/j.bja.2019.09.014.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Carpenter, Christopher R., Frances McFarland, Michael Avidan, Miles Berger, Sharon K. Inouye, Jason Karlawish, Frank R. Lin, et al. “Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series.” J Am Geriatr Soc 67, no. 10 (October 2019): 2011–17. https://doi.org/10.1111/jgs.16093.
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  - Mahanna-Gabrielli, Elizabeth, Katie J. Schenning, Lars I. Eriksson, Jeffrey N. Browndyke, Clinton B. Wright, Deborah J. Culley, Lis Evered, et al. “State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.” Br J Anaesth 123, no. 4 (October 2019): 464–78. https://doi.org/10.1016/j.bja.2019.07.004.
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  - Berger, Miles, Martin S. Angst, Deborah J. Culley, Catherine E. Price, David A. Scott, Robert A. Whittington, Roderic G. Eckenhoff, and Roderic G. Perioperative Neurotoxicity Working Group. “In Response.” Anesth Analg 129, no. 3 (September 2019): e112–13. https://doi.org/10.1213/ANE.0000000000004300.
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  - Ni, Katherine, Mary Cooter, Dhanesh K. Gupta, Jake Thomas, Thomas J. Hopkins, Timothy E. Miller, Michael L. James, Miklos D. Kertai, and Miles Berger. “Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.” Br J Anaesth 123, no. 3 (September 2019): 288–97. https://doi.org/10.1016/j.bja.2019.05.040.
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  - Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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  - Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.
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  - Yang, T., G. Xu, P. T. Newton, A. S. Chagin, S. Mkrtchian, M. Carlström, X. -. M. Zhang, et al. “Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.” Br J Anaesth 122, no. 3 (March 2019): 350–60. https://doi.org/10.1016/j.bja.2018.10.062.
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  - Brinkley, Tina E., Miles Berger, Kathryn E. Callahan, Robert A. Fieo, Lee A. Jennings, Jill K. Morris, Heather M. Wilkins, and Stephen B. Kritchevsky. “Corrigendum to: Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.” J Gerontol a Biol Sci Med Sci 74, no. 3 (February 15, 2019): 432. https://doi.org/10.1093/gerona/gly156.
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  - Smith, Patrick J., Jeffrey N. Browndyke, Zachary A. Monge, Todd B. Harshbarger, Michael L. James, Jeffrey G. Gaca, John H. Alexander, et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg 107, no. 1 (January 2019): 112–18. https://doi.org/10.1016/j.athoracsur.2018.07.056.
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  - Berger, Miles, Katie J. Schenning, Charles H. Brown, Stacie G. Deiner, Robert A. Whittington, Roderic G. Eckenhoff, Martin S. Angst, et al. “Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group.” Anesth Analg 127, no. 6 (December 2018): 1406–13. https://doi.org/10.1213/ANE.0000000000003841.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.” Br J Anaesth 121, no. 5 (November 2018): 1005–12. https://doi.org/10.1016/j.bja.2017.11.087.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.” Can J Anaesth 65, no. 11 (November 2018): 1248–57. https://doi.org/10.1007/s12630-018-1216-x.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.” Anesthesiology 129, no. 5 (November 2018): 872–79. https://doi.org/10.1097/ALN.0000000000002334.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.” Anesth Analg 127, no. 5 (November 2018): 1189–95. https://doi.org/10.1213/ANE.0000000000003634.
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  - Evered, Lis, Brendan Silbert, David S. Knopman, David A. Scott, Steven T. DeKosky, Lars S. Rasmussen, Esther S. Oh, et al. “Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.” Acta Anaesthesiol Scand 62, no. 10 (November 2018): 1473–80. https://doi.org/10.1111/aas.13250.
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  - Berger, Miles, Niccolò Terrando, S Kendall Smith, Jeffrey N. Browndyke, Mark F. Newman, and Joseph P. Mathew. “Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.” Anesthesiology 129, no. 4 (October 2018): 829–51. https://doi.org/10.1097/ALN.0000000000002194.
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  - Devinney, Michael J., Joseph P. Mathew, and Miles Berger. “Postoperative Delirium and Postoperative Cognitive Dysfunction: Two Sides of the Same Coin?” Anesthesiology 129, no. 3 (September 2018): 389–91. https://doi.org/10.1097/ALN.0000000000002338.
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  - Brinkley, Tina E., Miles Berger, Kathryn E. Callahan, Robert A. Fieo, Lee A. Jennings, Jill K. Morris, Heather M. Wilkins, and Stephen B. Kritchevsky. “Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.” J Gerontol a Biol Sci Med Sci 73, no. 9 (August 10, 2018): 1229–37. https://doi.org/10.1093/gerona/gly041.
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  - Cobb, Mary In-Ping Huang, Matthew Crowson, Rachael Mintz-Cole, Aatif M. Husain, Miles Berger, David Jang, and Patrick Codd. “Transnasal Transsphenoidal Elevation of Optic Chiasm in Secondary Empty Sella Syndrome Following Prolactinoma Treatment.” World Neurosurg 112 (April 2018): 250–53. https://doi.org/10.1016/j.wneu.2018.01.202.
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  - Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
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  - Browndyke, Jeffrey N., Miles Berger, Patrick J. Smith, Todd B. Harshbarger, Zachary A. Monge, Viral Panchal, Tiffany L. Bisanar, et al. “Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.” Hum Brain Mapp 39, no. 2 (February 2018): 985–1003. https://doi.org/10.1002/hbm.23898.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-20181.” J Alzheimers Dis 66, no. 1 (2018): 1–10. https://doi.org/10.3233/JAD-189004.
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  - Crowson, Matthew Gordon, Miles Berger, Grace C. McCarthy, and David B. Powers. “Orbitocerebral Impalement: Case Discussion and Management Algorithm.” Craniomaxillofac Trauma Reconstr 10, no. 3 (September 2017): 225–29. https://doi.org/10.1055/s-0036-1592098.
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  - Berger, Miles, Vikram Ponnusamy, Nathaniel Greene, Mary Cooter, Jacob W. Nadler, Allan Friedman, David L. McDonagh, et al. “The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.” Front Immunol 8 (2017): 1528. https://doi.org/10.3389/fimmu.2017.01528.
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  - Browndyke, Jeffrey N., Miles Berger, Todd B. Harshbarger, Patrick J. Smith, William White, Tiffany L. Bisanar, John H. Alexander, et al. “Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.” J Am Geriatr Soc 65, no. 1 (January 2017): e6–12. https://doi.org/10.1111/jgs.14534.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Klinger, Rebecca Y., Mary Cooter, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Thomas L. Ortel, Ian J. Welsby, et al. “Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.” Can J Anaesth 63, no. 11 (November 2016): 1223–32. https://doi.org/10.1007/s12630-016-0704-0.
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  - Berger, Miles, and Paul S. García. “Anesthetic Suppression of Thalamic High-Frequency Oscillations: Evidence that the Thalamus Is More Than Just a Gateway to Consciousness?” Anesth Analg 122, no. 6 (June 2016): 1737–39. https://doi.org/10.1213/ANE.0000000000001207.
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  - Berger, Miles, Jacob W. Nadler, Allan Friedman, David L. McDonagh, Ellen R. Bennett, Mary Cooter, Wenjing Qi, et al. “The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.” J Alzheimers Dis 52, no. 4 (April 15, 2016): 1299–1310. https://doi.org/10.3233/JAD-151190.
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  - Berger, Miles, Jacob W. Nadler, Jeffrey Browndyke, Niccolo Terrando, Vikram Ponnusamy, Harvey Jay Cohen, Heather E. Whitson, and Joseph P. Mathew. “Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.” Anesthesiol Clin 33, no. 3 (September 2015): 517–50. https://doi.org/10.1016/j.anclin.2015.05.008.
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  - Berger, Miles, Jeffrey Browndyke, and Joseph P. Mathew. “Intraoperative Glycemic Control to Prevent Delirium after Cardiac Surgery: Steering a Course between Scylla and Charybdis.” Anesthesiology 122, no. 6 (June 2015): 1186–88. https://doi.org/10.1097/ALN.0000000000000670.
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  - Berger, Miles, David W. Scheel, Hector Macias, Takeshi Miyatsuka, Hail Kim, Phuong Hoang, Greg M. Ku, et al. “Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.” Proc Natl Acad Sci U S A 112, no. 9 (March 3, 2015): 2888–93. https://doi.org/10.1073/pnas.1319378112.
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  - Berger, Miles, James Burke, Roderick Eckenhoff, and Joseph Mathew. “Alzheimer's disease, anesthesia, and surgery: a clinically focused review.” J Cardiothorac Vasc Anesth 28, no. 6 (December 2014): 1609–23. https://doi.org/10.1053/j.jvca.2014.04.014.
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  - McDonagh, David L., Miles Berger, Joseph P. Mathew, Carmelo Graffagnino, Carmelo A. Milano, and Mark F. Newman. “Neurological complications of cardiac surgery.” Lancet Neurol 13, no. 5 (May 2014): 490–502. https://doi.org/10.1016/S1474-4422(14)70004-3.
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  - Berger, Miles, Jacob Nadler, and Joseph P. Mathew. “Preventing delirium after cardiothoracic surgery: provocative but preliminary evidence for bispectral index monitoring.” Anesth Analg 118, no. 4 (April 2014): 706–7. https://doi.org/10.1213/ANE.0000000000000130.
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  - Berger, M., B. Philips-Bute, J. Guercio, T. J. Hopkins, M. L. James, C. O. Borel, D. S. Warner, and D. L. McDonagh. “A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.” Curr Med Res Opin 30, no. 2 (February 2014): 243–50. https://doi.org/10.1185/03007995.2013.855190.
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  - Berger, Miles, David S. Warner, and David L. McDonagh. “Volatile anesthetic sedation during therapeutic hypothermia after cardiac arrest in the ICU: a journey of a thousand miles begins with a single step.” Crit Care Med 42, no. 2 (February 2014): 494–95. https://doi.org/10.1097/01.ccm.0000435689.93091.d0.
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  - Hussain, Maria, Miles Berger, Roderic G. Eckenhoff, and Dallas P. Seitz. “General anesthetic and the risk of dementia in elderly patients: current insights.” Clin Interv Aging 9 (2014): 1619–28. https://doi.org/10.2147/CIA.S49680.
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  - Ishida, Kazuyoshi, Miles Berger, Jacob Nadler, and David S. Warner. “Anesthetic neuroprotection: antecedents and an appraisal of preclinical and clinical data quality.” Curr Pharm Des 20, no. 36 (2014): 5751–65. https://doi.org/10.2174/1381612820666140204111701.
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  - Khan, Shariq Ali, Miles Berger, Abhishek Agrawal, Mary Huang, Isaac Karikari, Shahid M. Nimjee, Ali R. Zomorodi, and David L. McDonagh. “Rapid ventricular pacing assisted hypotension in the management of sudden intraoperative hemorrhage during cerebral aneurysm clipping.” Asian J Neurosurg 9, no. 1 (January 2014): 33–35. https://doi.org/10.4103/1793-5482.131066.
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  - Mathew, Joseph P., William D. White, David B. Schinderle, Mihai V. Podgoreanu, Miles Berger, Carmelo A. Milano, Daniel T. Laskowitz, et al. “Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.” Stroke 44, no. 12 (December 2013): 3407–13. https://doi.org/10.1161/STROKEAHA.113.002703.
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  - Honig, Gerard, Angela Liou, Miles Berger, Michael S. German, and Laurence H. Tecott. “Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.” J Biomed Sci 17 (October 17, 2010): 82. https://doi.org/10.1186/1423-0127-17-82.
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  - Berger, Miles, John A. Gray, and Bryan L. Roth. “The expanded biology of serotonin.” Annu Rev Med 60 (2009): 355–66. https://doi.org/10.1146/annurev.med.60.042307.110802.
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  - Kushwaha, Neena, Shannon C. Harwood, Ariel M. Wilson, Miles Berger, Laurence H. Tecott, Bryan L. Roth, and Paul R. Albert. “Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.” Mol Pharmacol 69, no. 5 (May 2006): 1518–26. https://doi.org/10.1124/mol.105.019844.
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  - Berger, Miles, Sadna Budhu, Emily Lu, Yongmei Li, Devora Loike, Samuel C. Silverstein, and John D. Loike. “Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils.” J Leukoc Biol 71, no. 5 (May 2002): 798–806.
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  - Cooter, Mary, Thomas Bunning, Sarada S. Eleswarpu, Mitchell T. Heflin, Shelley McDonald, Sandhya Lagoo-Deenadalayan, Heather Whitson, Stacie G. Deiner, and Miles Berger. “A Processed EEG based Brain Anesthetic Resistance Index Predicts Postoperative Delirium in Older Adults: A Dual Center Study,” n.d. https://doi.org/10.1101/2021.01.07.21249360.
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- Book Sections
  - Doshi, A., R. Cabeza, and M. Berger. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” In Geriatric Anesthesiology: Third Edition, 145–60, 2017. https://doi.org/10.1007/978-3-319-66878-9_10.
    Full Text
  - Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 481–519, 2012.
- Conference Papers
  - Meier, Jennie, Miles Berger, Munro Cullum, Simon C. Lee, Herbert J. Zeh, Cynthia Brown, and Courtney Balentine. “Local Anesthesia Can Reduce Complications in Adults Undergoing Umbilical Hernia Repair.” In Journal of the American College of Surgeons, 231:S100–101, 2020.
    Link to Item
  - Ha, C., C. Giattino, J. Zhou, M. Cooter, K. Roberts, D. Crabtree, D. Oyeyemi, et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” In Journal of the American Geriatrics Society, 68:S179–S179. WILEY, 2020.
    Link to Item
  - Devinney, M. J., P. J. Smith, A. R. Spector, Y. Cheong, V. A. Wickenheisser, J. N. Browndyke, M. Cooter, J. P. Mathew, and M. Berger. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” In Journal of the American Geriatrics Society, 67:S178–S178. WILEY, 2019.
    Link to Item
  - Oyeyemi, D., H. Whitson, J. N. Browndyke, H. J. Cohen, J. P. Mathew, and M. Berger. “Depression, Anxiety and Postoperative Cognition in Older Adults.” In Journal of the American Geriatrics Society, 67:S338–S338. WILEY, 2019.
    Link to Item
  - Berger, M., J. Browndyke, M. Cooter, W. Bullock, B. Colin, J. Gadsden, E. Iboaya, et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” In Journal of the American Geriatrics Society, 66:S5–S5. WILEY, 2018.
    Link to Item
  - Bottiger, B., J. Klapper, V. Esposito, N. Hashmi, M. Berger, and P. Smith. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” In Journal of Heart and Lung Transplantation, 37:S252–S252. ELSEVIER SCIENCE INC, 2018.
    Link to Item
  - Cheong, Yee Ching Vanessa, Mary Cooter, Richard L. Huang, Heather E. Whitson, Harvey J. Cohen, Joseph P. Mathew, and Miles Berger. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” In Anesthesia and Analgesia, 126:353–56. LIPPINCOTT WILLIAMS & WILKINS, 2018.
    Link to Item
  - Devinney, M. J., M. Mclawhorn, B. Taicher, J. Hunting, and M. Berger. “Comparing CAM-ICU and 3D-CAM as early postoperative delirium screening tools.” In Journal of the American Geriatrics Society, 66:S172–73. WILEY, 2018.
    Link to Item
  - Devinney, Michael, Yee Ching Vanessa Cheong, Victoria Wickenheisser, Mary Cooter, Jennifer Dominguez, and Miles Berger. “IS OBSTRUCTIVE SLEEP APNEA ASSOCIATED WITH POSTOPERATIVE DELIRIUM AND COGNITIVE DECLINE?” In Anesthesia and Analgesia, 126:704–5. LIPPINCOTT WILLIAMS & WILKINS, 2018.
    Link to Item
  - Berger, M., K. Ni, and M. Cooter. “AGE DEPENDENT TRENDS IN ANESTHETIC ADMINISTRATION, AND THE AGE DEPENDENT DECREASE IN MAC: A SINGLE CENTER RETROSPECTIVE STUDY AND REGRESSION ANALYSIS OF PUBLISHED STUDIES.” In Anesthesia and Analgesia, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2016.
    Link to Item
  - Berger, M., P. J. Smith, F. Sbahi, J. Thomas, L. Snyder, and J. Blumenthal. “INTRAVENOUS IMMUNOGLOBULIN ADMINISTRATION IS ASSOCIATED WITH REDUCED DELIRIUM RATE AND DECREASED DELIRIUM DURATION IN LUNG TRANSPLANT RECIPIENTS- A SINGLE CENTER RETROSPECTIVE STUDY.” In Anesthesia and Analgesia, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2016.
    Link to Item
  - Raghunathan, K., S. L. McCartney, A. Barbeito, V. Khangulov, F. Peyerl, M. Berger, and A. Shaw. “ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY AMONG PATIENTS WITH AND WITHOUT PREEXISTING CHRONIC KIDNEY DISEASE: EFFECTS OF PERIOPERATIVE CRYSTALLOID CHOICE.” In Anesthesia and Analgesia, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2016.
    Link to Item
  - Simon, George R., Daniel Gomez, Mara B. Antonoff, Nguyen Quynh-Nhu, Emily Roarty, Kathryn A. Gold, Sunil Patel, et al. “MD Anderson Oncology Expert Advisor (TM) System (OEA (TM)): A Cognitive Computing Recommendations Application (App) for Lung Cancer.” In Journal of Thoracic Oncology, 10:S536–S536. ELSEVIER SCIENCE INC, 2015.
    Link to Item
  - Ford, Joel, Michael Berger, and Jillian L. Goldfarb. “Fabrication of activated biochars from avocado pits and their adsorption capacity for oxytetracycline from wastewater.” In Abstracts of Papers of the American Chemical Society, Vol. 248. AMER CHEMICAL SOC, 2014.
    Link to Item
  - Berger, M., D. McDonagh, J. Mathew, M. Newman, and M. James. “THE EFFECT OF PROPOFOL VERSUS ISOFLURANE ANESTHESIA ON HUMAN CSF MARKERS OF ALZHEIMER'S DISEASE- PRELIMINARY RESULTS OF A RANDOMIZED CONTROLLED TRIAL.” In Anesthesia and Analgesia, 116:162–162. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item
  - Lade, Amanda T., Michael Berger, Jillian L. Goldfarb, and Li Buessing. “Toxic gold? Bioavailability of olive oil waste phenols to plant matter.” In Abstracts of Papers of the American Chemical Society, Vol. 243. AMER CHEMICAL SOC, 2012.
    Link to Item
  - Metzger, Kayla L., Lyngine H. Calizo, Alisson Stephen, Miles Berger, Laurence H. Tecott, and Sheryl G. Beck. “Expression level of 5-HT1A receptor alters firing rate and concentration-dependency in YFP-labeled 5-HT dorsal raphe neurons.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.
    Link to Item
  - Loike, J. D., M. Berger, E. Lu, Y. M. Li, D. Loike, S. Budhu, and S. C. Silverstein. “Different Gi-coupled chemoattractant receptors signal qualitatively distinct functions in human neutrophils.” In Molecular Biology of the Cell, 12:324A-324A. AMER SOC CELL BIOLOGY, 2001.
    Link to Item
  - Berger, M., Y. M. Li, S. Budhu, S. C. Silverstein, and J. D. Loike. “Chemoattractant activation of beta(2) integrins and 5-lipoxygenase regulates neutrophil adhesion, migration oxidative burst.” In Molecular Biology of the Cell, 10:318A-318A. AMER SOC CELL BIOLOGY, 1999.
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