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Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure.

Publication ,  Journal Article
Nichols, MD; Choudhary, R; Kodali, S; Reichert, WM
Published in: Journal of biomedical materials research. Part B, Applied biomaterials
November 2013

In this study, the coagulation-induced resistance to flow in small-diameter nonpermeable Tygon tubes and permeable expanded polytetrafluoroethylene (ePTFE) vascular grafts was characterized by measuring the upstream pressure needed to purge the coagulum from the tube lumen. This purging pressure was monitored using a closed system that compressed the contents of the tubes at a constant rate. The pressure system was validated using a glycerin series with well-defined viscosities and precisely controlled reductions in cross-sectional area available for flow. This system was then used to systematically probe the upstream pressure buildup as fibrin glue, platelet-rich plasma (PRP) or whole blood coagulated in small-diameter Tygon tubing and or ePTFE grafts. The maximum purging pressures rose with increased clot maturity for fibrin glue, PRP, and whole blood in both Tygon and ePTFE tubes. Although the rapidly coagulating fibrin glue in nonpermeable Tygon tubing yielded highly consistent purging curves, the significantly longer and more variable clotting times of PRP and whole blood, and the porosity of ePTFE grafts, significantly diminished the consistency of the purging curves.

Duke Scholars

Published In

Journal of biomedical materials research. Part B, Applied biomaterials

DOI

EISSN

1552-4981

ISSN

1552-4973

Publication Date

November 2013

Volume

101

Issue

8

Start / End Page

1367 / 1376

Related Subject Headings

  • Viscosity
  • Thrombosis
  • Rheology
  • Pressure
  • Polytetrafluoroethylene
  • Platelet-Rich Plasma
  • Humans
  • Fibrin Tissue Adhesive
  • Blood Vessel Prosthesis
  • Blood Coagulation
 

Citation

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MLA
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Nichols, M. D., Choudhary, R., Kodali, S., & Reichert, W. M. (2013). Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 101(8), 1367–1376. https://doi.org/10.1002/jbm.b.32954
Nichols, Michael D., Rewa Choudhary, Santhisri Kodali, and William M. Reichert. “Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure.Journal of Biomedical Materials Research. Part B, Applied Biomaterials 101, no. 8 (November 2013): 1367–76. https://doi.org/10.1002/jbm.b.32954.
Nichols MD, Choudhary R, Kodali S, Reichert WM. Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure. Journal of biomedical materials research Part B, Applied biomaterials. 2013 Nov;101(8):1367–76.
Nichols, Michael D., et al. “Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure.Journal of Biomedical Materials Research. Part B, Applied Biomaterials, vol. 101, no. 8, Nov. 2013, pp. 1367–76. Epmc, doi:10.1002/jbm.b.32954.
Nichols MD, Choudhary R, Kodali S, Reichert WM. Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure. Journal of biomedical materials research Part B, Applied biomaterials. 2013 Nov;101(8):1367–1376.
Journal cover image

Published In

Journal of biomedical materials research. Part B, Applied biomaterials

DOI

EISSN

1552-4981

ISSN

1552-4973

Publication Date

November 2013

Volume

101

Issue

8

Start / End Page

1367 / 1376

Related Subject Headings

  • Viscosity
  • Thrombosis
  • Rheology
  • Pressure
  • Polytetrafluoroethylene
  • Platelet-Rich Plasma
  • Humans
  • Fibrin Tissue Adhesive
  • Blood Vessel Prosthesis
  • Blood Coagulation