3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement.

Journal Article (Journal Article)

With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outcomes and costs. Although clinical examination and standard computed tomography alone do not provide adequate information for understanding the complex temporal events that occur during an ischemic stroke, ultrasound imaging is well suited to the task of examining blood flow dynamics in real time and may allow for localization of a clot. A prototype bilateral 3-D ultrasound imaging system using two matrix array probes on either side of the head allows for correction of skull-induced aberration throughout two entire phased array imaging volumes. We investigated the feasibility of applying this custom correction technique in five healthy volunteers with Definity microbubble contrast enhancement. Subjects were scanned simultaneously via both temporal acoustic windows in 3-D color flow mode. The number of color flow voxels above a common threshold increased as a result of aberration correction in five of five subjects, with a mean increase of 33.9%. The percentage of large arteries visualized by 3-D color Doppler imaging increased from 46% without aberration correction to 60% with aberration correction.

Full Text

Duke Authors

Cited Authors

  • Lindsey, BD; Nicoletto, HA; Bennett, ER; Laskowitz, DT; Smith, SW

Published Date

  • January 2014

Published In

Volume / Issue

  • 40 / 1

Start / End Page

  • 90 - 101

PubMed ID

  • 24239360

Pubmed Central ID

  • PMC3849324

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2013.09.006


  • eng

Conference Location

  • England