Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.
Journal Article
Background
We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC). Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes have been recently characterized by in vitro assays but have not been evaluated in epidemiologic studies.Methods
Fifteen functional SNPs of the UGT2B17 and UGT2B15 genes, including cis-acting UGT2B gene SNPs, were genotyped in African American and Caucasian men (233 PC cases and 342 controls). Regression models were used to analyze the association between SNPs and PC risk.Results
After adjusting for race, age and BMI, we found that six UGT2B15 SNPs (rs4148269, rs3100, rs9994887, rs13112099, rs7686914 and rs7696472) were associated with an increased risk of PC in log-additive models (p < 0.05). A SNP cis-acting on UGT2B17 and UGT2B15 expression (rs17147338) was also associated with increased risk of prostate cancer (OR = 1.65, 95% CI = 1.00-2.70); while a stronger association among men with high Gleason sum was observed for SNPs rs4148269 and rs3100.Conclusions
Although small sample size limits inference, we report novel associations between UGT2B15 and UGT2B17 variants and PC risk. These associations with PC risk in men with high Gleason sum, more frequently found in African American men, support the relevance of genetic differences in the androgen metabolism pathway, which could explain, in part, the high incidence of PC among African American men. Larger studies are required.Full Text
Duke Authors
Cited Authors
- Vidal, AC; Tucker, C; Schildkraut, JM; Richardson, RM; McPhail, M; Freedland, SJ; Hoyo, C; Grant, DJ
Published Date
- November 22, 2013
Published In
Volume / Issue
- 13 /
Start / End Page
- 556 -
PubMed ID
- 24267955
Pubmed Central ID
- 24267955
Electronic International Standard Serial Number (EISSN)
- 1471-2407
International Standard Serial Number (ISSN)
- 1471-2407
Digital Object Identifier (DOI)
- 10.1186/1471-2407-13-556
Language
- eng