IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.

Published

Journal Article

BACKGROUND: Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically respond to corticosteroid treatment. CASE: We present a case of IgG4-related TIN in a patient with concomitant chronic lymphocytic leukemia. To our knowledge, IgG4-related TIN has not been associated with any hematological disorder such as chronic lymphocytic leukemia.
 CONCLUSION: We propose that all kidney biopsies with significant plasma cell infiltrate should be stained for IgG4 as response to treatment is common.

Full Text

Duke Authors

Cited Authors

  • Malone, AF; Sparks, MA; Howell, DN; Middleton, JP; Smith, SR; Lehrich, RW

Published Date

  • November 2013

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 1195 - 1198

PubMed ID

  • 24284523

Pubmed Central ID

  • 24284523

Electronic International Standard Serial Number (EISSN)

  • 1724-6059

Digital Object Identifier (DOI)

  • 10.5301/jn.5000298

Language

  • eng

Conference Location

  • Italy