Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast.
Publication
, Journal Article
Magwene, PM
Published in: Advances in experimental medicine and biology
January 2014
In diploid organisms, the frequency and nature of sexual cycles have a major impact on genome-wide patterns of heterozygosity. Recent population genomic surveys in the budding yeast, Saccharomyces cerevisiae, have revealed surprising levels of genomic heterozygosity in what has been traditionally considered a highly inbred organism. I review evidence and hypotheses regarding the generation, maintenance, and evolutionary consequences of genomic heterozygosity in S. cerevisiae. I propose that high levels of heterozygosity in S. cerevisiae, arising from population admixture due to human domestication, coupled with selfing during rare sexual cycles, can facilitate rapid adaptation to novel environments.
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Published In
Advances in experimental medicine and biology
DOI
EISSN
2214-8019
ISSN
0065-2598
Publication Date
January 2014
Volume
781
Start / End Page
37 / 48
Related Subject Headings
- Saccharomyces cerevisiae
- Humans
- Heterozygote
- Genome, Fungal
- General & Internal Medicine
- Evolution, Molecular
- Adaptation, Biological
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Magwene, P. M. (2014). Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in Experimental Medicine and Biology, 781, 37–48. https://doi.org/10.1007/978-94-007-7347-9_3
Magwene, Paul M. “Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast.” Advances in Experimental Medicine and Biology 781 (January 2014): 37–48. https://doi.org/10.1007/978-94-007-7347-9_3.
Magwene PM. Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in experimental medicine and biology. 2014 Jan;781:37–48.
Magwene, Paul M. “Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast.” Advances in Experimental Medicine and Biology, vol. 781, Jan. 2014, pp. 37–48. Epmc, doi:10.1007/978-94-007-7347-9_3.
Magwene PM. Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast. Advances in experimental medicine and biology. 2014 Jan;781:37–48.
Published In
Advances in experimental medicine and biology
DOI
EISSN
2214-8019
ISSN
0065-2598
Publication Date
January 2014
Volume
781
Start / End Page
37 / 48
Related Subject Headings
- Saccharomyces cerevisiae
- Humans
- Heterozygote
- Genome, Fungal
- General & Internal Medicine
- Evolution, Molecular
- Adaptation, Biological
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences