Treatment of genotype 1 HCV infection in the HIV coinfected patient in 2014.

Journal Article (Journal Article;Review)

Hepatitis C (HCV) coinfection is the leading cause of liver-related morbidity and is a leading cause of mortality in human immunodeficiency virus (HIV)-infected individuals in the antiretroviral therapy era. Direct-acting antiviral (DAA) therapies are transforming how HCV is treated with significant improvements in efficacy and tolerability. In this article, DAA agents expected to be available in 2014 are reviewed, including telaprevir, boceprevir, sofosbuvir, simeprevir, faldaprevir, and daclatasvir. Available data regarding clinical efficacy, adverse effects, and drug interactions in HIV-HCV coinfection are discussed. The management of adverse effects of HCV therapy and treatment considerations in patients with cirrhosis are also reviewed.

Full Text

Duke Authors

Cited Authors

  • Chastain, CA; Naggie, S

Published Date

  • December 2013

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 408 - 419

PubMed ID

  • 24272069

Pubmed Central ID

  • PMC4892376

Electronic International Standard Serial Number (EISSN)

  • 1548-3576

Digital Object Identifier (DOI)

  • 10.1007/s11904-013-0182-8


  • eng

Conference Location

  • United States