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Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome.

Publication ,  Journal Article
Philipp, CS; Faiz, AS; Beckman, MG; Grant, A; Bockenstedt, PL; Heit, JA; James, AH; Kulkarni, R; Manco-Johnson, MJ; Moll, S; Ortel, TL
Published in: Thromb Res
January 2014

INTRODUCTION: Black women have an increased risk of adverse pregnancy outcomes and the characteristics of thrombotic risk factors in this population are unknown. The objective of this study was to examine the racial differences in thrombotic risk factors among women with adverse pregnancy outcomes. METHODS: Uniform data were collected in women with adverse pregnancy outcomes (pregnancy losses, intrauterine growth restriction (IUGR), prematurity, placental abruption and preeclampsia) referred to Thrombosis Network Centers funded by the Centers for Disease Control and Prevention (CDC). RESULTS: Among 343 white and 66 black women seen for adverse pregnancy outcomes, protein S and antithrombin deficiencies were more common in black women. The prevalence of diagnosed thrombophilia was higher among whites compared to blacks largely due to Factor V Leiden mutation. The prevalence of a personal history of venous thromboembolism (VTE) did not differ significantly by race. A family history of VTE, thrombophilia, and stroke or myocardial infarction (MI) was higher among whites. Black women had a higher body mass index, and a higher prevalence of hypertension, while the prevalence of sickle cell disease was approximately 27 fold higher compared to the general US black population. CONCLUSIONS: Thrombotic risk factors differ significantly in white and black women with adverse pregnancy outcomes. Such differences highlight the importance of considering race separately when assessing thrombotic risk factors for adverse pregnancy outcomes.

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Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

January 2014

Volume

133

Issue

1

Start / End Page

108 / 111

Location

United States

Related Subject Headings

  • White People
  • United States
  • Thrombosis
  • Risk Factors
  • Pregnancy Complications, Hematologic
  • Pregnancy
  • Humans
  • Health Status Disparities
  • Female
  • Cardiovascular System & Hematology
 

Citation

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Chicago
ICMJE
MLA
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Philipp, C. S., Faiz, A. S., Beckman, M. G., Grant, A., Bockenstedt, P. L., Heit, J. A., … Ortel, T. L. (2014). Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome. Thromb Res, 133(1), 108–111. https://doi.org/10.1016/j.thromres.2013.10.035
Philipp, Claire S., Ambarina S. Faiz, Michele G. Beckman, Althea Grant, Paula L. Bockenstedt, John A. Heit, Andra H. James, et al. “Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome.Thromb Res 133, no. 1 (January 2014): 108–11. https://doi.org/10.1016/j.thromres.2013.10.035.
Philipp CS, Faiz AS, Beckman MG, Grant A, Bockenstedt PL, Heit JA, et al. Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome. Thromb Res. 2014 Jan;133(1):108–11.
Philipp, Claire S., et al. “Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome.Thromb Res, vol. 133, no. 1, Jan. 2014, pp. 108–11. Pubmed, doi:10.1016/j.thromres.2013.10.035.
Philipp CS, Faiz AS, Beckman MG, Grant A, Bockenstedt PL, Heit JA, James AH, Kulkarni R, Manco-Johnson MJ, Moll S, Ortel TL. Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome. Thromb Res. 2014 Jan;133(1):108–111.
Journal cover image

Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

January 2014

Volume

133

Issue

1

Start / End Page

108 / 111

Location

United States

Related Subject Headings

  • White People
  • United States
  • Thrombosis
  • Risk Factors
  • Pregnancy Complications, Hematologic
  • Pregnancy
  • Humans
  • Health Status Disparities
  • Female
  • Cardiovascular System & Hematology