Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF.

Journal Article (Clinical Trial, Phase III;Journal Article;Multicenter Study)

AIM: Patients hospitalized for acute heart failure (AHF) differ with respect of many clinical characteristics which may influence their prognosis and response to treatment. We have assessed possible differences in the effects of serelaxin on dyspnoea relief, 60 Day outcomes and 180 Day mortality across patient subgroups in the RELAX-AHF trial. METHODS AND RESULTS: Subgroups were based on pre-specified covariates (age, sex, race, geographic region, estimated glomerular filtration rate, time from presentation to randomization, baseline systolic blood pressure, history of diabetes, atrial fibrillation, ischaemic heart disease, cardiac devices, i.v. nitrates at randomization). Other covariates which may modify the efficacy of AHF treatment were also analysed. Subgroup analyses did not show any difference in the effects of serelaxin vs. placebo on dyspnoea relief or on the incidence of cardiovascular death or rehospitalizations for heart failure or renal failure at 60 days. Nominally significant interactions between some patient subgroups and the effects of serelaxin on 180 days cardiovascular and all-cause mortality were noted but should be interpreted cautiously due to the number of comparisons and the low incidence of deaths in the subgroups at lower risk. CONCLUSION: The effects of serelaxin vs. placebo appeared to be similar across subgroups of patients in RELAX-AHF.

Full Text

Duke Authors

Cited Authors

  • Metra, M; Ponikowski, P; Cotter, G; Davison, BA; Felker, GM; Filippatos, G; Greenberg, BH; Hua, TA; Severin, T; Unemori, E; Voors, AA; Teerlink, JR

Published Date

  • October 2013

Published In

Volume / Issue

  • 34 / 40

Start / End Page

  • 3128 - 3136

PubMed ID

  • 23999454

Pubmed Central ID

  • PMC3800849

Electronic International Standard Serial Number (EISSN)

  • 1522-9645

Digital Object Identifier (DOI)

  • 10.1093/eurheartj/eht371


  • eng

Conference Location

  • England