BAFF-ling autoantibodies.

Journal Article (Journal Article)

There is emerging evidence that autoantibodies directed against cytokines modulate the severity of autoimmune disease. Identification of cytokine-targeted autoantibodies in patients can be informative for diagnosis and predicting clinical outcome. In this issue of the JCI, Price and colleagues used a multiplex protein microarray to identify autoantibodies in serum from SLE patients. They found autoantibodies directed against the B cell-activating factor (BAFF) were associated with greater disease severity. This study highlights the contribution of cytokine-directed autoantibodies in disease and describes a valuable tool for identifying autoantibodies against serum antigens.

Full Text

Duke Authors

Cited Authors

  • Sarantopoulos, S; Su, MA

Published Date

  • December 2013

Published In

Volume / Issue

  • 123 / 12

Start / End Page

  • 5006 - 5008

PubMed ID

  • 24270413

Pubmed Central ID

  • PMC3859400

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI73166


  • eng

Conference Location

  • United States