A simulation environment for directional sensing as a phase separation process.
Journal Article (Journal Article)
The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.
Full Text
Duke Authors
Cited Authors
- de Candia, A; Gamba, A; Cavalli, F; Coniglio, A; Di Talia, S; Bussolino, F; Serini, G
Published Date
- March 20, 2007
Published In
Volume / Issue
- 2007 / 378
Start / End Page
- pl1 -
PubMed ID
- 17374853
Electronic International Standard Serial Number (EISSN)
- 1525-8882
Digital Object Identifier (DOI)
- 10.1126/stke.3782007pl1
Language
- eng
Conference Location
- United States