A simulation environment for directional sensing as a phase separation process.

Published online

Journal Article

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

Full Text

Duke Authors

Cited Authors

  • de Candia, A; Gamba, A; Cavalli, F; Coniglio, A; Di Talia, S; Bussolino, F; Serini, G

Published Date

  • March 20, 2007

Published In

Volume / Issue

  • 2007 / 378

Start / End Page

  • pl1 -

PubMed ID

  • 17374853

Electronic International Standard Serial Number (EISSN)

  • 1525-8882

Digital Object Identifier (DOI)

  • 10.1126/stke.3782007pl1

Language

  • eng

Conference Location

  • United States