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Role of repulsive factors in vascularization dynamics.

Publication ,  Journal Article
Di Talia, S; Gamba, A; Lamberti, F; Serini, G
Published in: Phys Rev E Stat Nonlin Soft Matter Phys
April 2006

Capillary networks are essential in vertebrates to supply tissues with nutrients. Experiments of in vitro capillary formation show that endothelial cells randomly spread on a gel matrix autonomously organize to form vascular networks with a characteristic length independent of the initial cell density. A mathematical model based on free cell migration and on cell cross-talk mediated by soluble chemical factors has been recently proposed and explains the main dynamical and geometrical properties of the networks. We extend this model introducing the action of repulsive factors and we show that their activity results in a larger degree of reorganization of cellular matter and in more robust control over the size of the growing vascular network.

Duke Scholars

Published In

Phys Rev E Stat Nonlin Soft Matter Phys

DOI

ISSN

1539-3755

Publication Date

April 2006

Volume

73

Issue

4 Pt 1

Start / End Page

041917

Location

United States

Related Subject Headings

  • Neovascularization, Physiologic
  • Models, Cardiovascular
  • Kinetics
  • Humans
  • Fluids & Plasmas
  • Endothelial Cells
  • Computer Simulation
  • Cells, Cultured
  • Cell Proliferation
  • Cell Movement
 

Citation

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Di Talia, S., Gamba, A., Lamberti, F., & Serini, G. (2006). Role of repulsive factors in vascularization dynamics. Phys Rev E Stat Nonlin Soft Matter Phys, 73(4 Pt 1), 041917. https://doi.org/10.1103/PhysRevE.73.041917
Di Talia, S., A. Gamba, F. Lamberti, and G. Serini. “Role of repulsive factors in vascularization dynamics.Phys Rev E Stat Nonlin Soft Matter Phys 73, no. 4 Pt 1 (April 2006): 041917. https://doi.org/10.1103/PhysRevE.73.041917.
Di Talia S, Gamba A, Lamberti F, Serini G. Role of repulsive factors in vascularization dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr;73(4 Pt 1):041917.
Di Talia, S., et al. “Role of repulsive factors in vascularization dynamics.Phys Rev E Stat Nonlin Soft Matter Phys, vol. 73, no. 4 Pt 1, Apr. 2006, p. 041917. Pubmed, doi:10.1103/PhysRevE.73.041917.
Di Talia S, Gamba A, Lamberti F, Serini G. Role of repulsive factors in vascularization dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr;73(4 Pt 1):041917.

Published In

Phys Rev E Stat Nonlin Soft Matter Phys

DOI

ISSN

1539-3755

Publication Date

April 2006

Volume

73

Issue

4 Pt 1

Start / End Page

041917

Location

United States

Related Subject Headings

  • Neovascularization, Physiologic
  • Models, Cardiovascular
  • Kinetics
  • Humans
  • Fluids & Plasmas
  • Endothelial Cells
  • Computer Simulation
  • Cells, Cultured
  • Cell Proliferation
  • Cell Movement