Cancer-related cognitive changes in children, adolescents and adult survivors of childhood cancers.


Journal Article

OBJECTIVES: To summarize the current knowledge about 1) cognitive changes associated with central nervous system-directed chemotherapy and cranial radiation among children with acute lymphoblastic leukemia and brain tumors and adult survivors; and 2) interventions designed to prevent or remediate the cognitive and academic problems associated with central nervous system-directed cancer treatment. DATA SOURCES: Classic and current databased publications. CONCLUSION: Future directions for research include 1) identification of sources of variability in long-term outcomes; 2) greater understanding of the developmental evolution of deficits across the survivor lifespan; and 3) interventions to treat and prevent negative outcomes following cancer therapy. IMPLICATIONS FOR NURSING PRACTICE: Pediatric oncology nurses have a critical role in identifying children and adolescents at risk for cognitive changes associated with cancer therapy, initiating referral for assessment of cognitive changes during and after therapy, and advocating for resources to enhance cognitive and academic outcomes.

Full Text

Duke Authors

Cited Authors

  • Ki Moore, IM; Hockenberry, MJ; Krull, KR

Published Date

  • November 2013

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 248 - 259

PubMed ID

  • 24183156

Pubmed Central ID

  • 24183156

Electronic International Standard Serial Number (EISSN)

  • 1878-3449

International Standard Serial Number (ISSN)

  • 0749-2081

Digital Object Identifier (DOI)

  • 10.1016/j.soncn.2013.08.005


  • eng