Isolated limb infusion as a model to test new agents to treat metastatic melanoma.

Journal Article (Journal Article;Review)

The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials.

Full Text

Duke Authors

Cited Authors

  • Lidsky, ME; Speicher, PJ; Jiang, B; Tsutsui, M; Tyler, DS

Published Date

  • March 2014

Published In

Volume / Issue

  • 109 / 4

Start / End Page

  • 357 - 365

PubMed ID

  • 24522940

Pubmed Central ID

  • PMC5161101

Electronic International Standard Serial Number (EISSN)

  • 1096-9098

Digital Object Identifier (DOI)

  • 10.1002/jso.23502


  • eng

Conference Location

  • United States