Heparin-induced thrombocytopenia.
Journal Article (Journal Article;Review)
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is a challenging diagnosis because of routine heparin use in hospitalized patients, the common occurrence of thrombocytopenia, and high rates of anti-PF4/heparin seroconversions in patients treated with heparin. Our diagnostic approach to HIT is presented here, underscoring critical elements of clinical and laboratory evaluation.
Full Text
Duke Authors
Cited Authors
- Lee, GM; Arepally, GM
Published Date
- 2013
Published In
Volume / Issue
- 2013 /
Start / End Page
- 668 - 674
PubMed ID
- 24319250
Pubmed Central ID
- PMC4153428
Electronic International Standard Serial Number (EISSN)
- 1520-4383
Digital Object Identifier (DOI)
- 10.1182/asheducation-2013.1.668
Language
- eng
Conference Location
- United States