Branch chain amino acids: biomarkers of health and disease.
Published
Journal Article (Review)
PURPOSE OF REVIEW: There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area. RECENT FINDINGS: Recent evidence demonstrates that BCAAs are associated with insulin resistance, type 2 diabetes, risk of cardiovascular disease, stage I and II chronic kidney disease and ischemic stroke. Further, circulating levels of BCAAs have the potential to predict populations at risk for cardiometabolic disease, type 2 diabetes and mortality from ischemic heart disease. Importantly, the relationship of BCAAs to insulin resistance is affected by the intake of fat in the diet as well as age. SUMMARY: Current evidence supports the potential use of BCAAs as biomarkers of disease. However, questions regarding the mechanisms underlying the relationship of BCAAs to disease process and severity need to be answered prior to the use of BCAAs as a biomarker in clinical practice.
Full Text
Duke Authors
Cited Authors
- Batch, BC; Hyland, K; Svetkey, LP
Published Date
- January 2014
Published In
Volume / Issue
- 17 / 1
Start / End Page
- 86 - 89
PubMed ID
- 24310057
Pubmed Central ID
- 24310057
Electronic International Standard Serial Number (EISSN)
- 1473-6519
Digital Object Identifier (DOI)
- 10.1097/MCO.0000000000000010
Language
- eng
Conference Location
- England