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Palliative treatment of metastatic colorectal cancer: what is the optimal approach?

Publication ,  Journal Article
Strickler, JH; Hurwitz, HI
Published in: Curr Oncol Rep
2014

Worldwide, colorectal cancer (CRC) is responsible for over 600,000 deaths annually and remains a significant public health concern. Because of therapeutic advancements over the past two decades, patients with metastatic CRC are living longer with an improved quality of life. This review will highlight recent trial evidence that improves outcomes for patients with metastatic disease. Topics will include the optimal use of first-line combination chemotherapy, bevacizumab in patients with advanced age or comorbidities, maintenance chemotherapy, first-line use of anti-EGFR therapies, first-line cetuximab versus bevacizumab, anti-angiogenic therapies past progression, and management of treatment-refractory disease. Clinical trial evidence will be presented, along with guidance on how to integrate recent evidence into clinical practice. Finally, this review will examine innovative drug development strategies, and will discuss potentially actionable targets identified by molecular testing.

Duke Scholars

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

2014

Volume

16

Issue

1

Start / End Page

363

Location

United States

Related Subject Headings

  • Quality of Life
  • Palliative Care
  • Oncology & Carcinogenesis
  • Maintenance Chemotherapy
  • Humans
  • Forecasting
  • ErbB Receptors
  • Colorectal Neoplasms
  • Clinical Trials as Topic
  • Cetuximab
 

Citation

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ICMJE
MLA
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Strickler, J. H., & Hurwitz, H. I. (2014). Palliative treatment of metastatic colorectal cancer: what is the optimal approach? Curr Oncol Rep, 16(1), 363. https://doi.org/10.1007/s11912-013-0363-z
Strickler, John H., and Herbert I. Hurwitz. “Palliative treatment of metastatic colorectal cancer: what is the optimal approach?Curr Oncol Rep 16, no. 1 (2014): 363. https://doi.org/10.1007/s11912-013-0363-z.
Strickler JH, Hurwitz HI. Palliative treatment of metastatic colorectal cancer: what is the optimal approach? Curr Oncol Rep. 2014;16(1):363.
Strickler, John H., and Herbert I. Hurwitz. “Palliative treatment of metastatic colorectal cancer: what is the optimal approach?Curr Oncol Rep, vol. 16, no. 1, 2014, p. 363. Pubmed, doi:10.1007/s11912-013-0363-z.
Strickler JH, Hurwitz HI. Palliative treatment of metastatic colorectal cancer: what is the optimal approach? Curr Oncol Rep. 2014;16(1):363.
Journal cover image

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

2014

Volume

16

Issue

1

Start / End Page

363

Location

United States

Related Subject Headings

  • Quality of Life
  • Palliative Care
  • Oncology & Carcinogenesis
  • Maintenance Chemotherapy
  • Humans
  • Forecasting
  • ErbB Receptors
  • Colorectal Neoplasms
  • Clinical Trials as Topic
  • Cetuximab