New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation.

Journal Article (Journal Article)

Minimal residual disease (MRD) is a complex topic that has been studied extensively in hematologic malignancies given its clinical implications related to prognosis. However, methods to monitor and treat MRD, especially after stem cell transplantation, are not well defined and vary in different disease processes. Alternative transplant strategies, such as reduced-intensity conditioning, have altered the way we assess and address MRD after transplantation. Development of new diagnostic tools have allowed for higher sensitivity and specificity of testing. Both targeted chemotherapeutic agents and immunotherapies have been developed to treat MRD in hopes of improving patient outcomes. This article aims to address ways to define and manipulate MRD specifically after stem cell transplantation.

Full Text

Duke Authors

Cited Authors

  • Rein, LA; Sung, AD; Rizzieri, DA

Published Date

  • February 2013

Published In

Volume / Issue

  • 2 / 1

PubMed ID

  • 24303095

Pubmed Central ID

  • PMC3841006

International Standard Serial Number (ISSN)

  • 2045-1393

Digital Object Identifier (DOI)

  • 10.2217/ijh.13.4


  • eng

Conference Location

  • England