Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.

Published

Journal Article

Methylphenidate (MPH) is commonly diverted for recreational use, but the neurobiological consequences of exposure to MPH at high, abused doses are not well defined. Here we show that MPH self-administration in rats increases dopamine transporter (DAT) levels and enhances the potency of MPH and amphetamine on dopamine responses and drug-seeking behaviours, without altering cocaine effects. Genetic overexpression of the DAT in mice mimics these effects, confirming that MPH self-administration-induced increases in DAT levels are sufficient to induce the changes. Further, this work outlines a basic mechanism by which increases in DAT levels, regardless of how they occur, are capable of increasing the rewarding and reinforcing effects of select psychostimulant drugs, and suggests that individuals with elevated DAT levels, such as ADHD sufferers, may be more susceptible to the addictive effects of amphetamine-like drugs.

Full Text

Duke Authors

Cited Authors

  • Calipari, ES; Ferris, MJ; Salahpour, A; Caron, MG; Jones, SR

Published Date

  • January 2013

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 2720 -

PubMed ID

  • 24193139

Pubmed Central ID

  • 24193139

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms3720

Language

  • eng