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CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.

Publication ,  Journal Article
Chauhan, SK; Saban, DR; Dohlman, TH; Dana, R
Published in: J Immunol
January 15, 2014

Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with APCs and T cells, interactions that require their proper homing to the lymphoid tissues. Using a well-characterized model of corneal allotransplantation, we demonstrate in this study that Tregs in the draining lymph nodes (LN) of allograft acceptors, but not rejectors, colocalize with APCs in the paracortical areas and express high levels of CCR7. In addition, we show that Treg expression of CCR7 is important not only for Treg homing to the draining LN, but also for optimal Treg suppressive function. Finally, we show that Tregs augmented for CCR7 expression by their ex vivo stimulation with the CCR7 ligand CCL21 show enhanced homing to the draining LN of allograft recipients and promote transplant survival. Together, these findings suggest that CCR7 expression is critical for Treg function and migration and that conditioning of Treg for maximal CCR7 expression may be a viable strategy for promoting allograft survival.

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 15, 2014

Volume

192

Issue

2

Start / End Page

817 / 823

Location

United States

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Receptors, CCR7
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphoid Tissue
  • Lymph Nodes
  • Immunology
  • Immune Tolerance
 

Citation

APA
Chicago
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MLA
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Chauhan, S. K., Saban, D. R., Dohlman, T. H., & Dana, R. (2014). CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. J Immunol, 192(2), 817–823. https://doi.org/10.4049/jimmunol.1203469
Chauhan, Sunil K., Daniel R. Saban, Thomas H. Dohlman, and Reza Dana. “CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.J Immunol 192, no. 2 (January 15, 2014): 817–23. https://doi.org/10.4049/jimmunol.1203469.
Chauhan SK, Saban DR, Dohlman TH, Dana R. CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. J Immunol. 2014 Jan 15;192(2):817–23.
Chauhan, Sunil K., et al. “CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.J Immunol, vol. 192, no. 2, Jan. 2014, pp. 817–23. Pubmed, doi:10.4049/jimmunol.1203469.
Chauhan SK, Saban DR, Dohlman TH, Dana R. CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. J Immunol. 2014 Jan 15;192(2):817–823.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 15, 2014

Volume

192

Issue

2

Start / End Page

817 / 823

Location

United States

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Receptors, CCR7
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lymphoid Tissue
  • Lymph Nodes
  • Immunology
  • Immune Tolerance