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The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis.

Publication ,  Journal Article
Reddick, KLB; Smrtka, MP; Grotegut, CA; James, AH; Brancazio, LR; Swamy, GK
Published in: Am J Perinatol
October 2014

OBJECTIVE: Pregnancy is associated with increased risk for thromboembolic events. Intermittent pneumatic compression (IPC) devices are the method of thromboprophylaxis in a nonpregnant population. The aim of this study was to examine the effects of IPC on markers of fibrinolysis during cesarean delivery. STUDY DESIGN: We conducted a randomized controlled trial from April 2009 to March 2010 of women undergoing scheduled elective cesarean delivery. Forty-nine women were randomized to IPCs or usual care. All participants had three blood samples obtained: (1) baseline, (2) 1 hour after randomization, and (3) 30 minutes after cesarean delivery. Tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), thrombin-antithrombin complex (TAT), plasminogen activator inhibitor-1 (PAI-1), and plasminogen activator inhibitor-2 (PAI-2) levels were analyzed in each sample using an enzyme-linked immunosorbent assay. Statistical analysis was performed using repeated measures two-way analysis of variance with α = 0.05. RESULTS: There was a time-dependent change in tPA, uPA, and PAI-1 levels following delivery but no difference in TAT and PAI-2 levels with time. There were no differences between women randomized to IPCs or usual care. CONCLUSION: Markers of fibrinolysis were not significantly altered by IPCs in this study of low-risk pregnant women. Further research regarding the mechanism and efficacy of IPCs in pregnant women is warranted.

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

October 2014

Volume

31

Issue

9

Start / End Page

735 / 740

Location

United States

Related Subject Headings

  • Young Adult
  • Urokinase-Type Plasminogen Activator
  • Tissue Plasminogen Activator
  • Pregnancy
  • Plasminogen Activator Inhibitor 2
  • Plasminogen Activator Inhibitor 1
  • Peptide Hydrolases
  • Obstetrics & Reproductive Medicine
  • Intermittent Pneumatic Compression Devices
  • Humans
 

Citation

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ICMJE
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Reddick, K. L. B., Smrtka, M. P., Grotegut, C. A., James, A. H., Brancazio, L. R., & Swamy, G. K. (2014). The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis. Am J Perinatol, 31(9), 735–740. https://doi.org/10.1055/s-0033-1359720
Reddick, Keisha L. B., Michael P. Smrtka, Chad A. Grotegut, Andra H. James, Leo R. Brancazio, and Geeta K. Swamy. “The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis.Am J Perinatol 31, no. 9 (October 2014): 735–40. https://doi.org/10.1055/s-0033-1359720.
Reddick KLB, Smrtka MP, Grotegut CA, James AH, Brancazio LR, Swamy GK. The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis. Am J Perinatol. 2014 Oct;31(9):735–40.
Reddick, Keisha L. B., et al. “The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis.Am J Perinatol, vol. 31, no. 9, Oct. 2014, pp. 735–40. Pubmed, doi:10.1055/s-0033-1359720.
Reddick KLB, Smrtka MP, Grotegut CA, James AH, Brancazio LR, Swamy GK. The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis. Am J Perinatol. 2014 Oct;31(9):735–740.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

October 2014

Volume

31

Issue

9

Start / End Page

735 / 740

Location

United States

Related Subject Headings

  • Young Adult
  • Urokinase-Type Plasminogen Activator
  • Tissue Plasminogen Activator
  • Pregnancy
  • Plasminogen Activator Inhibitor 2
  • Plasminogen Activator Inhibitor 1
  • Peptide Hydrolases
  • Obstetrics & Reproductive Medicine
  • Intermittent Pneumatic Compression Devices
  • Humans