Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles.

Journal Article (Review;Journal Article)

The field of tissue engineering involves design of high-fidelity tissue substitutes for predictive experimental assays in vitro and cell-based regenerative therapies in vivo. Design of striated muscle tissues, such as cardiac and skeletal muscle, has been particularly challenging due to a high metabolic demand and complex cellular organization and electromechanical function of the native tissues. Successful engineering of highly functional striated muscles may thus require creation of biomimetic culture conditions involving medium perfusion, electrical and mechanical stimulation. When optimized, these external cues are expected to synergistically and dynamically activate important intracellular signaling pathways leading to accelerated muscle growth and development. This review will discuss the use of different types of tissue culture bioreactors aimed at providing conditions for enhanced structural and functional maturation of engineered striated muscles.

Full Text

Duke Authors

Cited Authors

  • Rangarajan, S; Madden, L; Bursac, N

Published Date

  • July 2014

Published In

Volume / Issue

  • 42 / 7

Start / End Page

  • 1391 - 1405

PubMed ID

  • 24366526

Pubmed Central ID

  • PMC4069203

Electronic International Standard Serial Number (EISSN)

  • 1573-9686

International Standard Serial Number (ISSN)

  • 0090-6964

Digital Object Identifier (DOI)

  • 10.1007/s10439-013-0966-4


  • eng