Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates.

Published

Journal Article

Neuropathologic heterogeneity is often present among Alzheimer disease (AD) patients. We sought to determine whether amyloid imaging measures of AD are affected by concurrent pathologies. Thirty-eight clinically and pathologically defined AD and 17 nondemented patients with quantitative florbetapir F-18 (F-AV-45) positron emission tomography (PET) imaging during life and postmortem histological β-amyloid quantification and neuropathologic examination were assessed. AD patients were divided on the basis of concurrent pathologies, including those with Lewy bodies (LBs) (n = 21), white matter rarefaction (n = 27), severe cerebral amyloid angiopathy (n = 11), argyrophilic grains (n = 5), and TAR DNA binding protein-43 inclusions (n = 18). Many patients exhibited more than 1 type of concurrent pathology. The ratio of cortical to cerebellar amyloid imaging signal (SUVr) and immunohistochemical β-amyloid load were analyzed in 6 cortical regions of interest. All AD subgroups had strong and significant correlations between SUVr and histological β-amyloid measures (p μ 0.001). All AD subgroups had significantly greater amyloid measures versus nondemented patients, and mean amyloid measures did not significantly differ between AD subgroups. When comparing AD cases with and without each pathology, AD cases with LBs had significantly lower SUVr measures versus AD cases without LBs (p = 0.002); there were no other paired comparison differences. These findings indicate that florbetapir-PET imaging is not confounded by neuropathological heterogeneity within AD.

Full Text

Duke Authors

Cited Authors

  • Dugger, BN; Clark, CM; Serrano, G; Mariner, M; Bedell, BJ; Coleman, RE; Doraiswamy, PM; Lu, M; Fleisher, AS; Reiman, EM; Sabbagh, MN; Sadowsky, CH; Schneider, JA; Zehntner, SP; Carpenter, AP; Joshi, AD; Mintun, MA; Pontecorvo, MJ; Skovronsky, DM; Sue, LI; Beach, TG

Published Date

  • January 2014

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 72 - 80

PubMed ID

  • 24335535

Pubmed Central ID

  • 24335535

Electronic International Standard Serial Number (EISSN)

  • 1554-6578

Digital Object Identifier (DOI)

  • 10.1097/NEN.0000000000000028

Language

  • eng

Conference Location

  • England