Prognostic factors for squamous cell cancer of the parotid gland: an analysis of 2104 patients.


Journal Article

BACKGROUND: Parotid gland squamous cell cancer (SCC) occurs as metastasis from cutaneous SCC or primary malignancy. There is limited data on incidence, prognosis, and treatment outcomes. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database (1988-2009) identified 2104 adult patients with parotid SCC. RESULTS: SCC is the second most common parotid malignancy, and its incidence is increasing (annual percentage change 1.7%; ptrend  = .004). Age ≥85 years, tumor size ≥4 cm, extraparenchymal extension, cervical metastases, and distant metastases were independently associated with disease-specific mortality. Compared to no surgery, surgery was associated with improved 5-year disease-specific survival (DSS; 44.4% vs 71.0%; p < .001), whereas radiation alone was similar to no treatment (47.0% vs 41.6%; p = .28). CONCLUSION: Surgery and adjuvant radiation therapy (RT) are associated with improved survival compared to radiation alone and no treatment. Patients ≥85 years of age account for nearly 20% of all patients and have a poor prognosis independent of treatment.

Full Text

Cited Authors

  • Chen, MM; Roman, SA; Sosa, JA; Judson, BL

Published Date

  • January 2015

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 1 - 7

PubMed ID

  • 24339135

Pubmed Central ID

  • 24339135

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

International Standard Serial Number (ISSN)

  • 1043-3074

Digital Object Identifier (DOI)

  • 10.1002/hed.23566


  • eng