Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: A case report

Journal Article

We describe clinicopathologic and immunohistochemical features of an unusual case of cystic fibrosis manifesting in the cervix as a mass lesion, mimicking cervical adenocarcinoma. A 24-year-old nulligravida with cystic fibrosis developed heavy postcoital vaginal bleeding 4 months after starting oral contraceptives and was found to have a cervical mass. She underwent a loop electrosurgical excision of the mass, and microscopic examination revealed a florid endocervical proliferation, extending to the margins. This lesion was initially interpreted as an invasive, well-differentiated endocervical adenocarcinoma. However, on subsequent review, the lesion was found to have a low rate of proliferation, no evidence of an infiltrative growth pattern, and abundant acute inflammation. Given these findings and the absence of any residual endocervical lesion on a subsequent cold knife conization, we determined that this was a benign, likely reactive, lesion. This case, together with previous studies, suggests that women with cystic fibrosis can develop proliferative endocervical lesions and that oral contraceptives may contribute to their development. © 2013 International Society of Gynecological Pathologists.

Full Text

Duke Authors

Cited Authors

  • Previs, RA; Edwards, JM; Secord, AA; Nucci, MR; Bentley, RC; Hall, AHS

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 33 / 1

Start / End Page

  • 100 - 104

Electronic International Standard Serial Number (EISSN)

  • 1538-7151

International Standard Serial Number (ISSN)

  • 0277-1691

Digital Object Identifier (DOI)

  • 10.1097/PGP.0b013e318278b832

Citation Source

  • Scopus