Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

Journal Article

Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors. © 2013 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Choi, BD; Suryadevara, CM; Gedeon, PC; Herndon, JE; Sanchez-Perez, L; Bigner, DD; Sampson, JH

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 189 - 190

Electronic International Standard Serial Number (EISSN)

  • 1532-2653

International Standard Serial Number (ISSN)

  • 0967-5868

Digital Object Identifier (DOI)

  • 10.1016/j.jocn.2013.03.012

Citation Source

  • Scopus