Crystallographic model validation: From diagnosis to healing

Journal Article

Model validation has evolved from a passive final gatekeeping step to an ongoing diagnosis and healing process that enables significant improvement of accuracy. A recent phase of active development was spurred by the worldwide Protein Data Bank requiring data deposition and establishing Validation Task Force committees, by strong growth in high-quality reference data, by new speed and ease of computations, and by an upswing of interest in large molecular machines and structural ensembles. Progress includes automated correction methods, concise and user-friendly validation reports for referees and on the PDB websites, extension of error correction to RNA and error diagnosis to ligands, carbohydrates, and membrane proteins, and a good start on better methods for low resolution and for multiple conformations. © 2013 Elsevier Ltd.

Full Text

Duke Authors

Cited Authors

  • Richardson, JS; Prisant, MG; Richardson, DC

Published Date

  • 2013

Published In

Volume / Issue

  • 23 / 5

Start / End Page

  • 707 - 714

International Standard Serial Number (ISSN)

  • 0959-440X

Digital Object Identifier (DOI)

  • 10.1016/j.sbi.2013.06.004