Integrated approaches to understanding antipsychotic drug action at GPCRs.


Journal Article (Review)

The G-protein coupled receptor (GPCR) family of genes represents one of the largest druggable families of genes in the human genome. This is evident by the fact that approximately 30% of currently marketed drugs target GPCRs. However, many of these drugs are limited in their clinical potential as they are associated with debilitating side effects-a consequence of our incomplete understanding of their pharmacology and the signaling pathways regulated by GPCRs. Because of the limited range of tools available to resolve these issues, integrated approaches are required to fully understand the pharmacological action of drugs and the biochemical repertoire regulated by GPCRs. In this review we will focus on the action of antipsychotic drugs on certain monoamine GPCRs in the central nervous system (CNS) and the approaches being developed to elucidate their distinct pharmacology.

Full Text

Duke Authors

Cited Authors

  • Urs, NM; Nicholls, PJ; Caron, MG

Published Date

  • April 2014

Published In

Volume / Issue

  • 27 /

Start / End Page

  • 56 - 62

PubMed ID

  • 24680431

Pubmed Central ID

  • 24680431

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England