Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
Published
Journal Article
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
Full Text
Duke Authors
Cited Authors
- Phua, KKL; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK
Published Date
- June 2014
Published In
Volume / Issue
- 3 / 6
Start / End Page
- 837 - 842
PubMed ID
- 24339387
Pubmed Central ID
- 24339387
Electronic International Standard Serial Number (EISSN)
- 2192-2659
Digital Object Identifier (DOI)
- 10.1002/adhm.201300512
Language
- eng
Conference Location
- Germany