Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
Phua, KKL; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK
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