Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.

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Duke Authors

Dannull, Jens O.
Leong, Kam
Nair, Smita Kesavan

Cited Authors

Phua, KK; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK

Published Date

June 2014

Published In

Advanced healthcare materials

Volume / Issue

3 / 6

Start / End Page

837 - 842

PubMed ID

24339387

Electronic International Standard Serial Number (EISSN)

2192-2659

International Standard Serial Number (ISSN)

2192-2640

Digital Object Identifier (DOI)

10.1002/adhm.201300512

Language

Citation Source

Epmc