Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.

Full Text

Duke Authors

Cited Authors

  • Phua, KK; Boczkowski, D; Dannull, J; Pruitt, S; Leong, KW; Nair, SK

Published Date

  • June 2014

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 837 - 842

PubMed ID

  • 24339387

Electronic International Standard Serial Number (EISSN)

  • 2192-2659

International Standard Serial Number (ISSN)

  • 2192-2640

Digital Object Identifier (DOI)

  • 10.1002/adhm.201300512

Language

  • eng