Immune Complexes and Complement: Their Role in Host Defense and in Disease
The formation of circulating immune complexes is thought to play an etiologic role in many autoimmune and infectious diseases. These complexes activate a variety of effector systems that contribute to tissue pathology. One important, highly complex, effector system is comprised of the proteins of the complement system. Our current understanding of immune complexes, their formation, and their contribution to disease manifestations is reviewed. Similarly, we provide a brief review highlighting the chemistry, mechanisms of action, and function of the complement system proteins. © 2008 Blackwell Publishing.
Frank, MM; Garren Hester, C
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