Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme

We would like to correct a mistake in this report. We have recently discovered that the human medulloblastoma line D341 Med was cross-contaminated in our laboratory with the human rhabdomyosarcoma line TE-671. Accordingly, enhancement of nitrosourea activity following O6-benzylguanine-mediated depletion of alkyltransferase was demonstrated in this report in rhabdomyosarcoma and glioblastoma multiforme and not medulloblastoma. We have repeated these studies with the actual D341 Med xenografts (Table 1). These results indicate that O6-benzylguanine-mediated depletion of alkyltransferase can enhance nitrosourea activity against medulloblastoma and glioblastoma as originally stated in our report and, by virtue of the cross-contamination, extend these observations to human rhabdomyosarcoma as well. © 1994 Oxford University Press.

Duke Scholars

Author Henry Seth Friedman Neurosurgery, Neuro-Oncology