Hostile takeover: fungal protein promotes host cell invasion.

Journal Article (Journal Article)

The ability to suppress the immune system has lead to great advances in transplant technology and treatment of autoimmune diseases. Unfortunately, the immunosuppression of these patients has led to the rise of opportunistic infections by organisms that are recalcitrant to current prophylactic strategies. One such example is the increase of mucormycosis, an invasive infection caused by filamentous fungi of the order Mucorales. In this issue of the JCI, Gebremariam and colleagues determined that spore coat homolog (CotH) proteins are required for angioinvasion and that these proteins are unique to Mucorales. Their findings provide a potential therapeutic target for prevention and treatment of mucormycosis.

Full Text

Duke Authors

Cited Authors

  • Alspaugh, JA

Published Date

  • January 2014

Published In

Volume / Issue

  • 124 / 1

Start / End Page

  • 74 - 76

PubMed ID

  • 24355916

Pubmed Central ID

  • PMC3871258

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI73585


  • eng

Conference Location

  • United States