Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.

Published

Journal Article

Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs caused Ca(2+) release from IP(3)-sensitive stores and Ca(2+) entry, resulting in a slow and long-lasting exocytosis, DOR insertion, and CGRP release. In contrast, membrane depolarization or activation of vanilloid and P2Y(1) receptors induced a rapid DOR insertion. Thus, DOR activation induces a Ca(2+)-dependent insertion of DORs that is coupled to a release of excitatory neuropeptides, suggesting that treatment of inflammatory pain should include blockade of DORs.

Full Text

Duke Authors

Cited Authors

  • Bao, L; Jin, S-X; Zhang, C; Wang, L-H; Xu, Z-Z; Zhang, F-X; Wang, L-C; Ning, F-S; Cai, H-J; Guan, J-S; Xiao, H-S; Xu, Z-QD; He, C; Hökfelt, T; Zhou, Z; Zhang, X

Published Date

  • January 2003

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 121 - 133

PubMed ID

  • 12526778

Pubmed Central ID

  • 12526778

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(02)01103-0

Language

  • eng