Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.

Published

Journal Article

SCOPE: Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1 , UFB2 , and UFB3 . METHODS AND RESULTS: Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1 , B2 , and B3 (FB1 , FB2 and FB3 ), were detected in 100% of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. CONCLUSION: In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1 . More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.

Full Text

Duke Authors

Cited Authors

  • Torres, O; Matute, J; Gelineau-van Waes, J; Maddox, JR; Gregory, SG; Ashley-Koch, AE; Showker, JL; Zitomer, NC; Voss, KA; Riley, RT

Published Date

  • May 2014

Published In

Volume / Issue

  • 58 / 5

Start / End Page

  • 973 - 983

PubMed ID

  • 24375966

Pubmed Central ID

  • 24375966

Electronic International Standard Serial Number (EISSN)

  • 1613-4133

Digital Object Identifier (DOI)

  • 10.1002/mnfr.201300481

Language

  • eng

Conference Location

  • Germany