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Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.

Publication ,  Journal Article
Cotten, CM; Murtha, AP; Goldberg, RN; Grotegut, CA; Smith, PB; Goldstein, RF; Fisher, KA; Gustafson, KE; Waters-Pick, B; Swamy, GK; Rattray, B ...
Published in: J Pediatr
May 2014

OBJECTIVE: To assess feasibility and safety of providing autologous umbilical cord blood (UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: We enrolled infants in the intensive care nursery who were cooled for HIE and had available UCB in an open-label study of non-cyropreserved autologous volume- and red blood cell-reduced UCB cells (up to 4 doses adjusted for volume and red blood cell content, 1-5 × 10(7) cells/dose). We recorded UCB collection and cell infusion characteristics, and pre- and post-infusion vital signs. As exploratory analyses, we compared cell recipients' hospital outcomes (mortality, oral feeds at discharge) and 1-year survival with Bayley Scales of Infant and Toddler Development, 3rd edition scores ≥85 in 3 domains (cognitive, language, and motor development) with cooled infants who did not have available cells. RESULTS: Twenty-three infants were cooled and received cells. Median collection and infusion volumes were 36 and 4.3 mL. Vital signs including oxygen saturation were similar before and after infusions in the first 48 postnatal hours. Cell recipients and concurrent cooled infants had similar hospital outcomes. Thirteen of 18 (74%) cell recipients and 19 of 46 (41%) concurrent cooled infants with known 1-year outcomes survived with scores >85. CONCLUSIONS: Collection, preparation, and infusion of fresh autologous UCB cells for use in infants with HIE is feasible. A randomized double-blind study is needed.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

May 2014

Volume

164

Issue

5

Start / End Page

973 / 979.e1

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Severity of Illness Index
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant
 

Citation

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Cotten, C. M., Murtha, A. P., Goldberg, R. N., Grotegut, C. A., Smith, P. B., Goldstein, R. F., … Kurtzberg, J. (2014). Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr, 164(5), 973-979.e1. https://doi.org/10.1016/j.jpeds.2013.11.036
Cotten, C Michael, Amy P. Murtha, Ronald N. Goldberg, Chad A. Grotegut, P Brian Smith, Ricki F. Goldstein, Kimberley A. Fisher, et al. “Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.J Pediatr 164, no. 5 (May 2014): 973-979.e1. https://doi.org/10.1016/j.jpeds.2013.11.036.
Cotten CM, Murtha AP, Goldberg RN, Grotegut CA, Smith PB, Goldstein RF, et al. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr. 2014 May;164(5):973-979.e1.
Cotten, C. Michael, et al. “Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.J Pediatr, vol. 164, no. 5, May 2014, pp. 973-979.e1. Pubmed, doi:10.1016/j.jpeds.2013.11.036.
Cotten CM, Murtha AP, Goldberg RN, Grotegut CA, Smith PB, Goldstein RF, Fisher KA, Gustafson KE, Waters-Pick B, Swamy GK, Rattray B, Tan S, Kurtzberg J. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr. 2014 May;164(5):973-979.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

May 2014

Volume

164

Issue

5

Start / End Page

973 / 979.e1

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Severity of Illness Index
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant