Lung cancer screening with CT: Evaluation of radiologists anddifferent computer assisted detection software (CAD) as first andsecond readers for lung nodule detection at different dose levels
Objectives: To find the best pairing of first and second reader at highest sensitivity for detecting lungnodules with CT at various dose levels.Materials and methods: An anthropomorphic lung phantom and artificial lung nodules were used to simu-late screening CT-examination at standard dose (100 mAs, 120 kVp) and 8 different low dose levels, using120, 100 and 80 kVp combined with 100, 50 and 25 mAs. At each dose level 40 phantoms were randomlyfilled with 75 solid and 25 ground glass nodules (5-12 mm). Two radiologists and 3 different computeraided detection softwares (CAD) were paired to find the highest sensitivity.Results: Sensitivities at standard dose were 92%, 90%, 84%, 79% and 73% for reader 1, 2, CAD1, CAD2, CAD3,respectively. Combined sensitivity for human readers 1 and 2 improved to 97%, (p1 = 0.063, p2 = 0.016).Highest sensitivities - between 97% and 99.0% - were achieved by combining any radiologist with anyCAD at any dose level. Combining any two CADs, sensitivities between 85% and 88% were significantlylower than for radiologists combined with CAD (p < 0.03).Conclusions: Combination of a human observer with any of the tested CAD systems provide optimalsensitivity for lung nodule detection even at reduced dose at 25 mAs/80 kVp. © 2013 Elsevier Ireland Ltd. All rights reserved.
Christe, A; Leidolt, L; Huber, A; Steiger, P; Szucs-Farkas, Z; Roos, JE; Heverhagen, JT; Ebner, L
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