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Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.

Publication ,  Journal Article
Truskey, GA; Achneck, HE; Bursac, N; Chan, H; Cheng, CS; Fernandez, C; Hong, S; Jung, Y; Koves, T; Kraus, WE; Leong, K; Madden, L; Zhao, X ...
Published in: Stem Cell Res Ther
2013

Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different microphysiological organs and their flow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissue-engineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile flow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a non-invasive assessment of the health of the tissue and a way to measure the response to drugs and toxins.

Duke Scholars

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Published In

Stem Cell Res Ther

DOI

EISSN

1757-6512

Publication Date

2013

Volume

4 Suppl 1

Issue

Suppl 1

Start / End Page

S10

Location

England

Related Subject Headings

  • Toxicity Tests
  • Tissue Engineering
  • Stress, Mechanical
  • Myoblasts
  • Muscle, Skeletal
  • Microfluidic Analytical Techniques
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Endothelial Cells
  • Electric Stimulation
 

Citation

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Truskey, G. A., Achneck, H. E., Bursac, N., Chan, H., Cheng, C. S., Fernandez, C., … Zhao, X. (2013). Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Res Ther, 4 Suppl 1(Suppl 1), S10. https://doi.org/10.1186/scrt371
Truskey, George A., Hardean E. Achneck, Nenad Bursac, Hon Chan, Cindy S. Cheng, Cristina Fernandez, Sungmin Hong, et al. “Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.Stem Cell Res Ther 4 Suppl 1, no. Suppl 1 (2013): S10. https://doi.org/10.1186/scrt371.
Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, et al. Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Res Ther. 2013;4 Suppl 1(Suppl 1):S10.
Truskey, George A., et al. “Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.Stem Cell Res Ther, vol. 4 Suppl 1, no. Suppl 1, 2013, p. S10. Pubmed, doi:10.1186/scrt371.
Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, Hong S, Jung Y, Koves T, Kraus WE, Leong K, Madden L, Reichert WM, Zhao X. Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Res Ther. 2013;4 Suppl 1(Suppl 1):S10.
Journal cover image

Published In

Stem Cell Res Ther

DOI

EISSN

1757-6512

Publication Date

2013

Volume

4 Suppl 1

Issue

Suppl 1

Start / End Page

S10

Location

England

Related Subject Headings

  • Toxicity Tests
  • Tissue Engineering
  • Stress, Mechanical
  • Myoblasts
  • Muscle, Skeletal
  • Microfluidic Analytical Techniques
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Endothelial Cells
  • Electric Stimulation