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Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury.

Publication ,  Journal Article
Carbone, LD; Chin, AS; Lee, TA; Burns, SP; Svircev, JN; Hoenig, HM; Bailey, L; Weaver, FM
Published in: Arch Phys Med Rehabil
June 2014

OBJECTIVE: To determine the association between thiazide use and lower extremity fractures in patients who are men with a spinal cord injury (SCI). DESIGN: Cohort study from fiscal years 2002 to 2007. SETTING: Medical centers. PARTICIPANTS: Men (N=6969) with an SCI from the Veterans Affairs (VA) Spinal Cord Dysfunction (SCD) Registry, including 1433 users of thiazides and 5536 nonusers of thiazides. INTERVENTION: Thiazide use versus nonuse. MAIN OUTCOME MEASURE: Incident lower extremity fractures. RESULTS: Among the men, 21% in the VA SCD Registry (fiscal years 2002-2007) included in these analyses used thiazide diuretics. There were 832 incident lower extremity fractures over the time period of this study: 110 fractures (7.7%) in 1433 thiazide users and 722 fractures (13%) in 5536 nonusers of thiazides. In unadjusted and adjusted models alike, thiazide use was associated with at least a one-quarter risk reduction in lower extremity fracture at any given point in time (unadjusted: hazard ratio (HR)=.75; 95% confidence interval (CI), .59-.94; adjusted: HR=.74; 95% CI, .58-.95). CONCLUSIONS: Thiazide use is common in men with SCI and is associated with a decreased likelihood for lower extremity fractures.

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Published In

Arch Phys Med Rehabil

DOI

EISSN

1532-821X

Publication Date

June 2014

Volume

95

Issue

6

Start / End Page

1015 / 1020

Location

United States

Related Subject Headings

  • Spinal Cord Injuries
  • Sodium Chloride Symporter Inhibitors
  • Risk Assessment
  • Retrospective Studies
  • Rehabilitation
  • Registries
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lower Extremity
 

Citation

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Carbone, L. D., Chin, A. S., Lee, T. A., Burns, S. P., Svircev, J. N., Hoenig, H. M., … Weaver, F. M. (2014). Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. Arch Phys Med Rehabil, 95(6), 1015–1020. https://doi.org/10.1016/j.apmr.2013.12.013
Carbone, Laura D., Amy S. Chin, Todd A. Lee, Stephen P. Burns, Jelena N. Svircev, Helen M. Hoenig, Lauren Bailey, and Frances M. Weaver. “Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury.Arch Phys Med Rehabil 95, no. 6 (June 2014): 1015–20. https://doi.org/10.1016/j.apmr.2013.12.013.
Carbone LD, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, et al. Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. Arch Phys Med Rehabil. 2014 Jun;95(6):1015–20.
Carbone, Laura D., et al. “Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury.Arch Phys Med Rehabil, vol. 95, no. 6, June 2014, pp. 1015–20. Pubmed, doi:10.1016/j.apmr.2013.12.013.
Carbone LD, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, Bailey L, Weaver FM. Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. Arch Phys Med Rehabil. 2014 Jun;95(6):1015–1020.
Journal cover image

Published In

Arch Phys Med Rehabil

DOI

EISSN

1532-821X

Publication Date

June 2014

Volume

95

Issue

6

Start / End Page

1015 / 1020

Location

United States

Related Subject Headings

  • Spinal Cord Injuries
  • Sodium Chloride Symporter Inhibitors
  • Risk Assessment
  • Retrospective Studies
  • Rehabilitation
  • Registries
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lower Extremity