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Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation.

Publication ,  Journal Article
Cosgrove, ND; Al-Osaimi, AM; Sanoff, HK; Morris, MM; Read, PW; Cox, DG; Mann, JA; Argo, CK; Berg, CL; Pelletier, SJ; Maluf, DG; Wang, AY
Published in: Am J Transplant
February 2014

Many transplant centers use endoscopically directed brachytherapy to provide locoregional control in patients with otherwise incurable cholangiocarcinoma (CCA) who are awaiting liver transplantation (LT). The use of endoscopic retrograde cholangiopancreatography (ERCP)-directed photodynamic therapy (PDT) as an alternative to brachytherapy for providing locoregional control in this patient population has not been studied. The aim of this study was to report on our initial experience using ERCP-directed PDT to provide local control in patients with unresectable CCA who were awaiting LT. Patients with unresectable CCA who underwent protocol-driven neoadjuvant chemoradiation and ERCP-directed PDT with the intent of undergoing LT were reviewed. Four patients with confirmed or suspected CCA met the inclusion criteria for protocol LT. All four patients (100%) successfully underwent ERCP-directed PDT. All patients had chemoradiation dose delays, and two patients had recurrent cholangitis despite PDT. None of these patients had progressive locoregional disease or distant metastasis following PDT. All four patients (100%) underwent LT. Intention-to-treat disease-free survival was 75% at mean follow-up of 28.1 months. In summary, ERCP-directed PDT is a reasonably well tolerated and safe procedure that may have benefit by maintaining locoregional tumor control in patients with CCA who are awaiting LT.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2014

Volume

14

Issue

2

Start / End Page

466 / 471

Location

United States

Related Subject Headings

  • Waiting Lists
  • Surgery
  • Retrospective Studies
  • Prognosis
  • Photochemotherapy
  • Patient Selection
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Liver Transplantation
 

Citation

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MLA
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Cosgrove, N. D., Al-Osaimi, A. M., Sanoff, H. K., Morris, M. M., Read, P. W., Cox, D. G., … Wang, A. Y. (2014). Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. Am J Transplant, 14(2), 466–471. https://doi.org/10.1111/ajt.12597
Cosgrove, N. D., A. M. Al-Osaimi, H. K. Sanoff, M. M. Morris, P. W. Read, D. G. Cox, J. A. Mann, et al. “Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation.Am J Transplant 14, no. 2 (February 2014): 466–71. https://doi.org/10.1111/ajt.12597.
Cosgrove ND, Al-Osaimi AM, Sanoff HK, Morris MM, Read PW, Cox DG, et al. Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. Am J Transplant. 2014 Feb;14(2):466–71.
Cosgrove, N. D., et al. “Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation.Am J Transplant, vol. 14, no. 2, Feb. 2014, pp. 466–71. Pubmed, doi:10.1111/ajt.12597.
Cosgrove ND, Al-Osaimi AM, Sanoff HK, Morris MM, Read PW, Cox DG, Mann JA, Argo CK, Berg CL, Pelletier SJ, Maluf DG, Wang AY. Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. Am J Transplant. 2014 Feb;14(2):466–471.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2014

Volume

14

Issue

2

Start / End Page

466 / 471

Location

United States

Related Subject Headings

  • Waiting Lists
  • Surgery
  • Retrospective Studies
  • Prognosis
  • Photochemotherapy
  • Patient Selection
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Liver Transplantation