Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.

Journal Article (Journal Article)

We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was more frequent than expected for children with DS-ALL (54%) than for non-DS ALL. These data suggest leukemic relapse rather than transplant toxicity is the most important cause of treatment failure. Advancements in leukemia control are especially needed for improvement in HCT outcomes for DS-ALL.

Full Text

Duke Authors

Cited Authors

  • Hitzler, JK; He, W; Doyle, J; Cairo, M; Camitta, BM; Chan, KW; Diaz Perez, MA; Fraser, C; Gross, TG; Horan, JT; Kennedy-Nasser, AA; Kitko, C; Kurtzberg, J; Lehmann, L; O'Brien, T; Pulsipher, MA; Smith, FO; Zhang, M-J; Eapen, M; Carpenter, PA; CIBMTR Pediatric Cancer Working Committee,

Published Date

  • June 2014

Published In

Volume / Issue

  • 61 / 6

Start / End Page

  • 1126 - 1128

PubMed ID

  • 24391118

Pubmed Central ID

  • PMC4080799

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.24918


  • eng

Conference Location

  • United States