Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.
Publication
, Journal Article
Hitzler, JK; He, W; Doyle, J; Cairo, M; Camitta, BM; Chan, KW; Diaz Perez, MA; Fraser, C; Gross, TG; Horan, JT; Kennedy-Nasser, AA; Kitko, C ...
Published in: Pediatr Blood Cancer
June 2014
We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was more frequent than expected for children with DS-ALL (54%) than for non-DS ALL. These data suggest leukemic relapse rather than transplant toxicity is the most important cause of treatment failure. Advancements in leukemia control are especially needed for improvement in HCT outcomes for DS-ALL.
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Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
June 2014
Volume
61
Issue
6
Start / End Page
1126 / 1128
Location
United States
Related Subject Headings
- Whole-Body Irradiation
- Treatment Outcome
- Transplantation Conditioning
- Tacrolimus
- Salvage Therapy
- Retrospective Studies
- Remission Induction
- Registries
- Recurrence
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
Citation
APA
Chicago
ICMJE
MLA
NLM
Hitzler, J. K., He, W., Doyle, J., Cairo, M., Camitta, B. M., Chan, K. W., … CIBMTR Pediatric Cancer Working Committee, . (2014). Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer, 61(6), 1126–1128. https://doi.org/10.1002/pbc.24918
Hitzler, Johann K., Wensheng He, John Doyle, Mitchell Cairo, Bruce M. Camitta, Ka Wah Chan, Miguel A. Diaz Perez, et al. “Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.” Pediatr Blood Cancer 61, no. 6 (June 2014): 1126–28. https://doi.org/10.1002/pbc.24918.
Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, et al. Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer. 2014 Jun;61(6):1126–8.
Hitzler, Johann K., et al. “Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.” Pediatr Blood Cancer, vol. 61, no. 6, June 2014, pp. 1126–28. Pubmed, doi:10.1002/pbc.24918.
Hitzler JK, He W, Doyle J, Cairo M, Camitta BM, Chan KW, Diaz Perez MA, Fraser C, Gross TG, Horan JT, Kennedy-Nasser AA, Kitko C, Kurtzberg J, Lehmann L, O’Brien T, Pulsipher MA, Smith FO, Zhang M-J, Eapen M, Carpenter PA, CIBMTR Pediatric Cancer Working Committee. Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatr Blood Cancer. 2014 Jun;61(6):1126–1128.
Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
June 2014
Volume
61
Issue
6
Start / End Page
1126 / 1128
Location
United States
Related Subject Headings
- Whole-Body Irradiation
- Treatment Outcome
- Transplantation Conditioning
- Tacrolimus
- Salvage Therapy
- Retrospective Studies
- Remission Induction
- Registries
- Recurrence
- Precursor Cell Lymphoblastic Leukemia-Lymphoma