One-pot synthesis of 3-azido- and 3-aminopiperidines by intramolecular cyclization of unsaturated amines.
Journal Article (Journal Article)
A highly efficient one-pot synthesis of 3-azidopiperidines has been achieved by an intramolecular cyclization of unsaturated amines that allows for the nucleophilic installation of an azide moiety. This method unlocks the versatile employment of the azide functionality in the preparation and biological studies of piperidine-containing structures. This strategy has been expanded for the direct incorporation of a variety of nitrogen nucleophiles, and thus it provides a rapid and modular synthesis of 3-amino and 3-amidopiperidines of important pharmaceutical and biological relevance. Particularly noteworthy is that the regioselectivity of this transformation enables the formation of the anti-Markovnikov-type adduct, complementing Markovnikov-based olefin amino functionalization methods.
Full Text
Duke Authors
Cited Authors
- Ortiz, GX; Kang, B; Wang, Q
Published Date
- January 2014
Published In
Volume / Issue
- 79 / 2
Start / End Page
- 571 - 581
PubMed ID
- 24359462
Electronic International Standard Serial Number (EISSN)
- 1520-6904
International Standard Serial Number (ISSN)
- 0022-3263
Digital Object Identifier (DOI)
- 10.1021/jo4022666
Language
- eng