CMR imaging with rapid visual T1 assessment predicts mortality in patients suspected of cardiac amyloidosis.

Published

Journal Article

This study tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA.In patients with confirmed CA, delayed-enhancement cardiac magnetic resonance (DE-CMR) frequently shows a diffuse, global hyperenhancement (HE) pattern. However, imaging is often technically challenging, and the prognostic significance of diffuse HE is unclear.Ninety consecutive patients referred for suspected CA and 64 hypertensive patients with left ventricular hypertrophy (LVH) were prospectively enrolled and underwent a modified DE-CMR protocol. After gadolinium administration a method for rapid, visual T1 assessment was used to identify the presence of diffuse HE during the scan, allowing immediate optimization of settings for the conventional DE-CMR that followed. The primary endpoint was all-cause mortality.Among patients with suspected CA, 66% (59 of 90) demonstrated HE, with 81% (48 of 59) of these meeting pre-specified visual T1 assessment criteria for diffuse HE. Among hypertensive LVH patients, 6% (4 of 64) had HE, with none having diffuse HE. During 29 months of follow-up (interquartile range: 12 to 44 months), there were 50 (56%) deaths in patients with suspected CA and 4 (6%) in patients with hypertensive LVH. Multivariable analysis demonstrated that the presence of diffuse HE was the most important predictor of death in the group with suspected CA (hazard ratio: 5.5, 95% confidence interval: 2.7 to 11.0; p < 0.0001) and in the population as a whole (hazard ratio: 6.0, 95% confidence interval 3.0 to 12.1; p < 0.0001). Among 25 patients with myocardial histology obtained during follow-up, the sensitivity, specificity, and accuracy of diffuse HE in the diagnosis of CA were 93%, 70%, and 84%, respectively.Among patients suspected of CA, the presence of diffuse HE by visual T1 assessment accurately identifies patients with histologically-proven CA and is a strong predictor of mortality.

Full Text

Duke Authors

Cited Authors

  • White, JA; Kim, HW; Shah, D; Fine, N; Kim, K-Y; Wendell, DC; Al-Jaroudi, W; Parker, M; Patel, M; Gwadry-Sridhar, F; Judd, RM; Kim, RJ

Published Date

  • February 2014

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 143 - 156

PubMed ID

  • 24412191

Pubmed Central ID

  • 24412191

Electronic International Standard Serial Number (EISSN)

  • 1876-7591

International Standard Serial Number (ISSN)

  • 1936-878X

Digital Object Identifier (DOI)

  • 10.1016/j.jcmg.2013.09.019

Language

  • eng