Treatment of genotype 1 HCV infection in the HIV coinfected patient in 2014

Journal Article

Hepatitis C (HCV) coinfection is the leading cause of liver-related morbidity and is a leading cause of mortality in human immunodeficiency virus (HIV)-infected individuals in the antiretroviral therapy era. Direct-acting antiviral (DAA) therapies are transforming how HCV is treated with significant improvements in efficacy and tolerability. In this article, DAA agents expected to be available in 2014 are reviewed, including telaprevir, boceprevir, sofosbuvir, simeprevir, faldaprevir, and daclatasvir. Available data regarding clinical efficacy, adverse effects, and drug interactions in HIV-HCV coinfection are discussed. The management of adverse effects of HCV therapy and treatment considerations in patients with cirrhosis are also reviewed. © 2013 Springer Science+Business Media N ew York.

Full Text

Duke Authors

Cited Authors

  • Chastain, CA; Naggie, S

Published Date

  • December 1, 2013

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 408 - 419

Electronic International Standard Serial Number (EISSN)

  • 1548-3576

International Standard Serial Number (ISSN)

  • 1548-3568

Digital Object Identifier (DOI)

  • 10.1007/s11904-013-0182-8

Citation Source

  • Scopus