Role of interleukin-32 in chronic rhinosinusitis.


Journal Article (Review)

IL-32 is a recently described proinflammatory cytokine and has been reported to be involved in inflammatory diseases. The purpose of this review is to discuss the role of IL-32 in chronic rhinosinusitis (CRS).Two groups have recently reported data regarding the expression of IL-32 in CRS. IL-32 was induced by IFN-γ, TNF-α, dsRNA, and incubation with Th1 cells in primary nasal epithelial cells. IL-32 may be elevated in epithelial cells from patients with CRS without nasal polyps. IL-32 was significantly elevated in whole sinonasal tissue samples of nasal polyps compared with control tissue. IL-32 mRNA expression positively correlated with mRNA for CD3 and macrophage mannose receptor in nasal polyp tissue. Immunohistochemical studies demonstrated localization of IL-32 in epithelium, CD3(+) and CD68(+) cells, suggesting that epithelial cells, T cells, and macrophages are the major IL-32-producing cells in CRS. Activation of these cell types may trigger IL-32-related inflammation in CRS.Elevated levels of IL-32 may play a role in the pathogenesis of CRS through its role as a proinflammatory cytokine and as an endogenous enhancer of pathogen-dependent cytokine production.

Full Text

Cited Authors

  • Keswani, A; Kern, RC; Schleimer, RP; Kato, A

Published Date

  • February 2013

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 13 - 18

PubMed ID

  • 23242112

Pubmed Central ID

  • 23242112

Electronic International Standard Serial Number (EISSN)

  • 1473-6322

International Standard Serial Number (ISSN)

  • 1528-4050

Digital Object Identifier (DOI)

  • 10.1097/ACI.0b013e32835b35d5


  • eng