The role of neuroendocrine pathways in prognosis after stroke.

Published

Journal Article (Review)

A number of neuroendocrine changes have been described after stroke, which may serve adaptive or deleterious functions. The neuroendocrine changes include activation of the hypothalamo-pituitary-adrenal axis, sympathetic nervous system and alterations of several hormonal levels. Alterations of the HPA axis, increased catecholamines, natriuretic peptides and, decreased melatonin and IGF-1 levels are associated with poor post-stroke outcome, although there is no definitive proof of causality. Therefore, it remains to be established whether alteration of neuroendocrine responses could be used as a potential therapeutic target to improve stroke outcome. This article gives an overview of the major neuroendocrine pathways altered by stroke and highlights their potential for clinical use and further neurotherapeutic development by summarizing the evidence for their association with stroke outcome including functional outcome, post-stroke infection, delirium, depression and stroke-related myocardial injury.

Full Text

Duke Authors

Cited Authors

  • El Husseini, N; Laskowitz, DT

Published Date

  • February 2014

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 217 - 232

PubMed ID

  • 24428141

Pubmed Central ID

  • 24428141

Electronic International Standard Serial Number (EISSN)

  • 1744-8360

Digital Object Identifier (DOI)

  • 10.1586/14737175.2014.877841

Language

  • eng

Conference Location

  • England