Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.

Published

Journal Article

Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury-induced long-term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain.

Full Text

Duke Authors

Cited Authors

  • Xu, Z-Z; Liu, X-J; Berta, T; Park, C-K; Lü, N; Serhan, CN; Ji, R-R

Published Date

  • September 2013

Published In

Volume / Issue

  • 74 / 3

Start / End Page

  • 490 - 495

PubMed ID

  • 23686636

Pubmed Central ID

  • 23686636

Electronic International Standard Serial Number (EISSN)

  • 1531-8249

Digital Object Identifier (DOI)

  • 10.1002/ana.23928

Language

  • eng

Conference Location

  • United States