Risk assessment to predict arterial and venous events in patients undergoing percutaneous coronary intervention.


Journal Article

Atherosclerosis and venous thromboembolism (VTE) share common risk factors. We set to assess the strength of the association between atherosclerosis risk factors and disease manifestation, and VTE, in patients with coronary artery disease undergoing percutaneous coronary intervention. We pooled data from 6 global randomized controlled trials assessing coronary stenting (ENDEAVOR and SIRIUS programs), developed separate risk scores to predict major adverse cardiac and cerebrovascular events (MACCEs: cardiac death, myocardial infarction, and stroke) and VTE, and compared their performance. The 5-year rates of MACCE and VTE were 10.8% and 2.04%, respectively. Selected predictors for MACCE performed equally well in predicting VTE (area under the receiver-operating characteristic curve [AUC] 0.651 vs 0.672), and selected predictors for VTE performed equally well in predicting MACCE (AUC 0.699 vs 0.620). Ejection fraction and age were associated with both MACCE and VTE. These findings support the concept of overlapping pathophysiology of VTE and atherothrombosis.

Full Text

Duke Authors

Cited Authors

  • Vardi, M; Piazza, G; Pencina, MJ; Burke, DA; Lei, L; Goldhaber, SZ; Cutlip, DE

Published Date

  • July 2014

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • 478 - 483

PubMed ID

  • 24431382

Pubmed Central ID

  • 24431382

Electronic International Standard Serial Number (EISSN)

  • 1938-2723

Digital Object Identifier (DOI)

  • 10.1177/1076029613517166


  • eng

Conference Location

  • United States