Pretreatment FDG-PET standardized uptake value as a prognostic factor for outcome in head and neck cancer.


Journal Article

BACKGROUND: We studied the potential prognostic significance of pretreatment 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) standardized uptake value (SUV) in squamous cell carcinoma of the head and neck (SCCHN). METHODS: A retrospective review of the pretreatment FDG-PET scans of 60 patients with SCCHN was performed. All patients received radiotherapy and 37 also received concurrent chemotherapy. SUV was calculated by 2 nuclear-medicine physicians who were blinded to the clinical data. Disease-free survival (DFS) was analyzed with respect to SUV (and other potential prognostic factors). RESULTS: The median SUV was 7.2 (range, 1-24.7); 34 patients (57%) had SUV < 9.0 compared with 26 patients (43%) with an SUV > or = 9.0. The group with low SUV had significantly better 2-year DFS compared with the high SUV group (72% vs 37%), p = .007. On multivariate analysis, stage and age were also associated with DFS, but SUV remained an independent predictor of DFS (hazard ratio: 1.08; p = .016). CONCLUSION: SUV was significantly associated with outcome after modern definitive therapy of SCCHN.

Full Text

Cited Authors

  • Machtay, M; Natwa, M; Andrel, J; Hyslop, T; Anne, PR; Lavarino, J; Intenzo, CM; Keane, W

Published Date

  • February 2009

Published In

Volume / Issue

  • 31 / 2

Start / End Page

  • 195 - 201

PubMed ID

  • 19107945

Pubmed Central ID

  • 19107945

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.20942


  • eng

Conference Location

  • United States